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Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.
Villar-Piqué A, Lopes da Fonseca T, Sant'Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF. Villar-Piqué A, et al. Among authors: outeiro tf. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6506-E6515. doi: 10.1073/pnas.1606791113. Epub 2016 Oct 5. Proc Natl Acad Sci U S A. 2016. PMID: 27708160 Free PMC article.
The role of LRRK2 in cell signalling.
Harvey K, Outeiro TF. Harvey K, et al. Among authors: outeiro tf. Biochem Soc Trans. 2019 Feb 28;47(1):197-207. doi: 10.1042/BST20180464. Epub 2018 Dec 21. Biochem Soc Trans. 2019. PMID: 30578345 Review.
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Ghanem SS, Majbour NK, Vaikath NN, Ardah MT, Erskine D, Jensen NM, Fayyad M, Sudhakaran IP, Vasili E, Melachroinou K, Abdi IY, Poggiolini I, Santos P, Dorn A, Carloni P, Vekrellis K, Attems J, McKeith I, Outeiro TF, Jensen PH, El-Agnaf OMA. Ghanem SS, et al. Among authors: outeiro tf. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2109617119. doi: 10.1073/pnas.2109617119. Epub 2022 Mar 30. Proc Natl Acad Sci U S A. 2022. PMID: 35353605 Free PMC article.
Aromaticity at position 39 in α-synuclein: A modulator of amyloid fibril assembly and membrane-bound conformations.
Buratti FA, Boeffinger N, Garro HA, Flores JS, Hita FJ, Gonçalves PDC, Copello FDR, Lizarraga L, Rossetti G, Carloni P, Zweckstetter M, Outeiro TF, Eimer S, Griesinger C, Fernández CO. Buratti FA, et al. Among authors: outeiro tf. Protein Sci. 2022 Jul;31(7):e4360. doi: 10.1002/pro.4360. Protein Sci. 2022. PMID: 35762717 Free PMC article.
Epigenetics of the Synapse in Neurodegeneration.
Xylaki M, Atzler B, Outeiro TF. Xylaki M, et al. Among authors: outeiro tf. Curr Neurol Neurosci Rep. 2019 Aug 23;19(10):72. doi: 10.1007/s11910-019-0995-y. Curr Neurol Neurosci Rep. 2019. PMID: 31440934 Free PMC article. Review.
328 results