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ATP8B1 is essential for maintaining normal hearing.
Stapelbroek JM, Peters TA, van Beurden DH, Curfs JH, Joosten A, Beynon AJ, van Leeuwen BM, van der Velden LM, Bull L, Oude Elferink RP, van Zanten BA, Klomp LW, Houwen RH. Stapelbroek JM, et al. Among authors: oude elferink rp. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9709-14. doi: 10.1073/pnas.0807919106. Epub 2009 May 28. Proc Natl Acad Sci U S A. 2009. PMID: 19478059 Free PMC article.
Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport.
Paulusma CC, Groen A, Kunne C, Ho-Mok KS, Spijkerboer AL, Rudi de Waart D, Hoek FJ, Vreeling H, Hoeben KA, van Marle J, Pawlikowska L, Bull LN, Hofmann AF, Knisely AS, Oude Elferink RP. Paulusma CC, et al. Among authors: oude elferink rp. Hepatology. 2006 Jul;44(1):195-204. doi: 10.1002/hep.21212. Hepatology. 2006. PMID: 16799980
Intestinal bile salt absorption in Atp8b1 deficient mice.
Groen A, Kunne C, Paulusma CC, Kramer W, Agellon LB, Bull LN, Oude Elferink RP. Groen A, et al. Among authors: oude elferink rp. J Hepatol. 2007 Jul;47(1):114-22. doi: 10.1016/j.jhep.2007.02.011. Epub 2007 Mar 7. J Hepatol. 2007. PMID: 17448567
Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice.
Groen A, Kunne C, Jongsma G, van den Oever K, Mok KS, Petruzzelli M, Vrins CL, Bull L, Paulusma CC, Oude Elferink RP. Groen A, et al. Among authors: oude elferink rp. Gastroenterology. 2008 Jun;134(7):2091-100. doi: 10.1053/j.gastro.2008.02.097. Epub 2008 Mar 8. Gastroenterology. 2008. PMID: 18466903
Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.
Groen A, Romero MR, Kunne C, Hoosdally SJ, Dixon PH, Wooding C, Williamson C, Seppen J, Van den Oever K, Mok KS, Paulusma CC, Linton KJ, Oude Elferink RP. Groen A, et al. Among authors: oude elferink rp. Gastroenterology. 2011 Nov;141(5):1927-37.e1-4. doi: 10.1053/j.gastro.2011.07.042. Epub 2011 Aug 4. Gastroenterology. 2011. PMID: 21820390
232 results