Otzen DE - Search Results

1

Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State.

Kurnik M, Sahin C, Andersen CB, Lorenzen N, Giehm L, Mohammad-Beigi H, Jessen CM, Pedersen JS, Christiansen G, Petersen SV, Staal R, Krishnamurthy G, Pitts K, Reinhart PH, Mulder FAA, Mente S, Hirst WD, Otzen DE. Kurnik M, et al. Among authors: otzen de. Cell Chem Biol. 2018 Nov 15;25(11):1389-1402.e9. doi: 10.1016/j.chembiol.2018.08.005. Epub 2018 Sep 6. Cell Chem Biol. 2018. PMID: 30197194 Free article.

2

The changing face of glucagon fibrillation: structural polymorphism and conformational imprinting.

Pedersen JS, Dikov D, Flink JL, Hjuler HA, Christiansen G, Otzen DE. Pedersen JS, et al. Among authors: otzen de. J Mol Biol. 2006 Jan 20;355(3):501-23. doi: 10.1016/j.jmb.2005.09.100. Epub 2005 Nov 9. J Mol Biol. 2006. PMID: 16321400

3

Heparin binding induces a conformational change in pigment epithelium-derived factor.

Valnickova Z, Petersen SV, Nielsen SB, Otzen DE, Enghild JJ. Valnickova Z, et al. Among authors: otzen de. J Biol Chem. 2007 Mar 2;282(9):6661-7. doi: 10.1074/jbc.M610471200. Epub 2007 Jan 2. J Biol Chem. 2007. PMID: 17202143 Free article.

4

Aggregation as the basis for complex behaviour of cutinase in different denaturants.

Otzen DE, Giehm L, Baptista RP, Kristensen SR, Melo EP, Pedersen S. Otzen DE, et al. Biochim Biophys Acta. 2007 Feb;1774(2):323-33. doi: 10.1016/j.bbapap.2006.11.012. Epub 2006 Nov 30. Biochim Biophys Acta. 2007. PMID: 17208524

5

Glucagon amyloid-like fibril morphology is selected via morphology-dependent growth inhibition.

Andersen CB, Otzen D, Christiansen G, Rischel C. Andersen CB, et al. Biochemistry. 2007 Jun 19;46(24):7314-24. doi: 10.1021/bi6025374. Epub 2007 May 25. Biochemistry. 2007. PMID: 17523599

6

Aggregation of S6 in a quasi-native state by sub-micellar SDS.

Otzen DE, Nesgaard LW, Andersen KK, Hansen JH, Christiansen G, Doe H, Sehgal P. Otzen DE, et al. Biochim Biophys Acta. 2008 Feb;1784(2):400-14. doi: 10.1016/j.bbapap.2007.11.010. Epub 2007 Nov 28. Biochim Biophys Acta. 2008. PMID: 18083130

7

Dendrimers destabilize proteins in a generation-dependent manner involving electrostatic interactions.

Giehm L, Christensen C, Boas U, Heegaard PM, Otzen DE. Giehm L, et al. Among authors: otzen de. Biopolymers. 2008 Jun;89(6):522-9. doi: 10.1002/bip.20921. Biopolymers. 2008. PMID: 18203113

8

Spectroscopic evidence for the existence of an obligate pre-fibrillar oligomer during glucagon fibrillation.

Christensen PA, Pedersen JS, Christiansen G, Otzen DE. Christensen PA, et al. Among authors: otzen de. FEBS Lett. 2008 Apr 16;582(9):1341-5. doi: 10.1016/j.febslet.2008.03.017. Epub 2008 Mar 20. FEBS Lett. 2008. PMID: 18358836 Free article.

9

An unusual intrinsically disordered protein from the model legume Lotus japonicus stabilizes proteins in vitro.

Haaning S, Radutoiu S, Hoffmann SV, Dittmer J, Giehm L, Otzen DE, Stougaard J. Haaning S, et al. Among authors: otzen de. J Biol Chem. 2008 Nov 7;283(45):31142-52. doi: 10.1074/jbc.M805024200. Epub 2008 Sep 8. J Biol Chem. 2008. PMID: 18779323 Free PMC article.

10

Kinetic partitioning between aggregation and vesicle permeabilization by modified ADan.

Nesgaard L, Vad B, Christiansen G, Otzen D. Nesgaard L, et al. Biochim Biophys Acta. 2009 Jan;1794(1):84-93. doi: 10.1016/j.bbapap.2008.09.021. Epub 2008 Oct 15. Biochim Biophys Acta. 2009. PMID: 18977466

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