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In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.
Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, Binning JM, Tonelli M, Olson MA, Davey RA, Ready JM, Basler CF, Amarasinghe GK. Brown CS, et al. Among authors: otwinowski z. J Mol Biol. 2014 May 15;426(10):2045-58. doi: 10.1016/j.jmb.2014.01.010. Epub 2014 Feb 1. J Mol Biol. 2014. PMID: 24495995 Free PMC article.
Structure of Escherichia coli RutC, a member of the YjgF family and putative aminoacrylate peracid reductase of the rut operon.
Knapik AA, Petkowski JJ, Otwinowski Z, Cymborowski MT, Cooper DR, Chruszcz M, Krajewska WM, Minor W. Knapik AA, et al. Among authors: otwinowski z. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1294-9. doi: 10.1107/S1744309112041796. Epub 2012 Oct 26. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 23143235 Free PMC article.
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Cymborowski M, Klimecka M, Chruszcz M, Zimmerman MD, Shumilin IA, Borek D, Lazarski K, Joachimiak A, Otwinowski Z, Anderson W, Minor W. Cymborowski M, et al. Among authors: otwinowski z. J Struct Funct Genomics. 2010 Sep;11(3):211-21. doi: 10.1007/s10969-010-9092-9. Epub 2010 Jun 6. J Struct Funct Genomics. 2010. PMID: 20526815 Free PMC article.
103 results