Otvos RA - Search Results

1

Drug Discovery on Natural Products: From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays.

Otvos RA, Still KBM, Somsen GW, Smit AB, Kool J. Otvos RA, et al. SLAS Discov. 2019 Mar;24(3):362-385. doi: 10.1177/2472555218822098. Epub 2019 Jan 25. SLAS Discov. 2019. PMID: 30682257 Free PMC article. Review.

2

At-Line Cellular Screening Methodology for Bioactives in Mixtures Targeting the α7-Nicotinic Acetylcholine Receptor.

Otvos RA, Mladic M, Arias-Alpizar G, Niessen WM, Somsen GW, Smit AB, Kool J. Otvos RA, et al. J Biomol Screen. 2016 Jun;21(5):459-67. doi: 10.1177/1087057115625307. Epub 2016 Jan 6. J Biomol Screen. 2016. PMID: 26738519

3

An efficient analytical platform for on-line microfluidic profiling of neuroactive snake venoms towards nicotinic receptor affinity.

Heus F, Vonk F, Otvos RA, Bruyneel B, Smit AB, Lingeman H, Richardson M, Niessen WM, Kool J. Heus F, et al. Among authors: otvos ra. Toxicon. 2013 Jan;61:112-24. doi: 10.1016/j.toxicon.2012.11.002. Epub 2012 Nov 14. Toxicon. 2013. PMID: 23159399

4

Analytical workflow for rapid screening and purification of bioactives from venom proteomes.

Otvos RA, Heus F, Vonk FJ, Halff J, Bruyneel B, Paliukhovich I, Smit AB, Niessen WM, Kool J. Otvos RA, et al. Toxicon. 2013 Dec 15;76:270-81. doi: 10.1016/j.toxicon.2013.10.013. Epub 2013 Oct 16. Toxicon. 2013. PMID: 24140918

5

Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.

Otvos RA, Iyer JK, van Elk R, Ulens C, Niessen WM, Somsen GW, Kini RM, Smit AB, Kool J. Otvos RA, et al. Toxins (Basel). 2015 Jun 24;7(7):2336-53. doi: 10.3390/toxins7072336. Toxins (Basel). 2015. PMID: 26114334 Free PMC article.

6

Microfluidic Chip-Based Online Screening Coupled to Mass Spectrometry: Identification of Inhibitors of Thrombin and Factor Xa.

Iyer JK, Otvos RA, Kool J, Kini RM. Iyer JK, et al. Among authors: otvos ra. J Biomol Screen. 2016 Feb;21(2):212-20. doi: 10.1177/1087057115602648. Epub 2015 Aug 31. J Biomol Screen. 2016. PMID: 26323281

7

Development of an Online Cell-Based Bioactivity Screening Method by Coupling Liquid Chromatography to Flow Cytometry with Parallel Mass Spectrometry.

Otvos RA, van Nierop P, Niessen WM, Kini RM, Somsen GW, Smit AB, Kool J. Otvos RA, et al. Anal Chem. 2016 May 3;88(9):4825-32. doi: 10.1021/acs.analchem.6b00455. Epub 2016 Apr 20. Anal Chem. 2016. PMID: 27046509

8

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling.

Slagboom J, Otvos RA, Cardoso FC, Iyer J, Visser JC, van Doodewaerd BR, McCleary RJR, Niessen WMA, Somsen GW, Lewis RJ, Kini RM, Smit AB, Casewell NR, Kool J. Slagboom J, et al. Among authors: otvos ra. Toxicon. 2018 Jun 15;148:213-222. doi: 10.1016/j.toxicon.2018.04.022. Epub 2018 May 4. Toxicon. 2018. PMID: 29730150 Free article.

9

Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail.

Heus F, Otvos RA, Aspers RL, van Elk R, Halff JI, Ehlers AW, Dutertre S, Lewis RJ, Wijmenga S, Smit AB, Niessen WM, Kool J. Heus F, et al. Among authors: otvos ra. Biology (Basel). 2014 Feb 13;3(1):139-56. doi: 10.3390/biology3010139. Biology (Basel). 2014. PMID: 24833338 Free PMC article.

10

Novel mechanism of modulation at a ligand-gated ion channel; action of 5-Cl-indole at the 5-HT₃ A receptor.

Powell AD, Grafton G, Roberts A, Larkin S, O'Neill N, Palandri J, Otvos R, Cooper AJ, Ulens C, Barnes NM. Powell AD, et al. Br J Pharmacol. 2016 Dec;173(24):3467-3479. doi: 10.1111/bph.13638. Epub 2016 Nov 1. Br J Pharmacol. 2016. PMID: 27677804 Free PMC article.

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