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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1977 3
1978 1
1979 1
1981 1
1984 2
1985 4
1986 4
1987 4
1988 6
1989 5
1990 7
1991 3
1992 4
1993 9
1994 9
1995 7
1996 4
1997 10
1998 4
1999 9
2000 7
2001 13
2002 20
2003 25
2004 27
2005 27
2006 26
2007 47
2008 48
2009 48
2010 64
2011 93
2012 109
2013 142
2014 172
2015 232
2016 243
2017 273
2018 271
2019 336
2020 373
2021 351
2022 300
2023 250
2024 97

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3,278 results

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Page 1
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.
Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D. Mevissen TE, et al. Cell. 2013 Jul 3;154(1):169-84. doi: 10.1016/j.cell.2013.05.046. Cell. 2013. PMID: 23827681 Free PMC article.
Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. ...Additional Ub-binding domains, the ubiquitinated sequence in the substrate, and defined S1' and S2 Ub-binding sites on the OTU domain ena …
Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members regulate cell-signaling cascades. ...Addi …
Bacterial usurpation of the OTU deubiquitinase fold.
Pruneda JN, Nguyen JV, Nagai H, Kubori T. Pruneda JN, et al. FEBS J. 2023 Jan 13:10.1111/febs.16725. doi: 10.1111/febs.16725. Online ahead of print. FEBS J. 2023. PMID: 36636866 Free article. Review.
To exert control over host cellular functions, some pathogenic bacteria have usurped the OTU deubiquitinase fold as a secreted virulence factor that interferes with ubiquitination inside infected cells. ...Understanding bacterial OTU deubiquitinases holds the potent …
To exert control over host cellular functions, some pathogenic bacteria have usurped the OTU deubiquitinase fold as a secreted virule …
The function and regulation of OTU deubiquitinases.
Du J, Fu L, Sui Y, Zhang L. Du J, et al. Front Med. 2020 Oct;14(5):542-563. doi: 10.1007/s11684-019-0734-4. Epub 2019 Dec 28. Front Med. 2020. PMID: 31884527 Review.
Recently, much progress has been made in the DUBs. In humans, the ovarian tumor protease (OTU) subfamily of DUBs includes 16 members, most of which mediate cell signaling cascades. ...
Recently, much progress has been made in the DUBs. In humans, the ovarian tumor protease (OTU) subfamily of DUBs includes 16 members, …
Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii.
Wilde ML, Ruparel U, Klemm T, Lee VV, Calleja DJ, Komander D, Tonkin CJ. Wilde ML, et al. Life Sci Alliance. 2023 Mar 23;6(6):e202201710. doi: 10.26508/lsa.202201710. Print 2023 Jun. Life Sci Alliance. 2023. PMID: 36958824 Free PMC article.
This study presents comprehensive characterisation of Toxoplasma OTU DUBs. AlphaFold-guided structural analysis not only confirmed functional orthologues found across eukaryotes, but also identified apicomplexan-specific enzymes, subsequently enabling discovery of a crypti …
This study presents comprehensive characterisation of Toxoplasma OTU DUBs. AlphaFold-guided structural analysis not only confirmed fu …
Viral OTU deubiquitinases: a structural and functional comparison.
Bailey-Elkin BA, van Kasteren PB, Snijder EJ, Kikkert M, Mark BL. Bailey-Elkin BA, et al. PLoS Pathog. 2014 Mar 27;10(3):e1003894. doi: 10.1371/journal.ppat.1003894. eCollection 2014 Mar. PLoS Pathog. 2014. PMID: 24676359 Free PMC article. Review.
Recent studies have revealed that proteases encoded by three very diverse RNA virus groups share structural similarity with enzymes of the Ovarian Tumor (OTU) superfamily of deubiquitinases (DUBs). The publication of the latest of these reports in quick succession prevente …
Recent studies have revealed that proteases encoded by three very diverse RNA virus groups share structural similarity with enzymes of the O …
Phylogeny-guided microbiome OTU-specific association test (POST).
Huang C, Callahan BJ, Wu MC, Holloway ST, Brochu H, Lu W, Peng X, Tzeng JY. Huang C, et al. Microbiome. 2022 Jun 7;10(1):86. doi: 10.1186/s40168-022-01266-3. Microbiome. 2022. PMID: 35668471 Free PMC article.
RESULTS: In this work, we propose a local collapsing test called phylogeny-guided microbiome OTU-specific association test (POST). In POST, whether or not to borrow information and how much information to borrow from the neighboring OTUs in the phylogenetic tree are superv …
RESULTS: In this work, we propose a local collapsing test called phylogeny-guided microbiome OTU-specific association test (POST). In …
Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection.
Shin D, Bhattacharya A, Cheng YL, Alonso MC, Mehdipour AR, van der Heden van Noort GJ, Ovaa H, Hummer G, Dikic I. Shin D, et al. Elife. 2020 Nov 13;9:e58277. doi: 10.7554/eLife.58277. Elife. 2020. PMID: 33185526 Free PMC article.
The crystal structure of the LotC catalytic core (LotC(14-310)) was determined at 2.4 A. Unlike the classical OTU-family, the LOT-family shows an extended helical lobe between the Cys-loop and the variable loop, which defines them as a unique class of OTU-DUBs. ...T …
The crystal structure of the LotC catalytic core (LotC(14-310)) was determined at 2.4 A. Unlike the classical OTU-family, the LOT-fam …
Identification and characterization of diverse OTU deubiquitinases in bacteria.
Schubert AF, Nguyen JV, Franklin TG, Geurink PP, Roberts CG, Sanderson DJ, Miller LN, Ovaa H, Hofmann K, Pruneda JN, Komander D. Schubert AF, et al. EMBO J. 2020 Aug 3;39(15):e105127. doi: 10.15252/embj.2020105127. Epub 2020 Jun 22. EMBO J. 2020. PMID: 32567101 Free PMC article.
Viral pathogens have also extensively co-opted the OTU fold to subvert host signaling, but the extent to which bacteria utilize the OTU fold was unknown. ...By determining the ubiquitin-bound structures of two examples, we demonstrate the novel strategies that have …
Viral pathogens have also extensively co-opted the OTU fold to subvert host signaling, but the extent to which bacteria utilize the …
Identification of first-in-class plasmodium OTU inhibitors with potent anti-malarial activity.
Siyah P, Akgol S, Durdagi S, Kocabas F. Siyah P, et al. Biochem J. 2021 Sep 30;478(18):3445-3466. doi: 10.1042/BCJ20210481. Biochem J. 2021. PMID: 34486667
OTU proteases antagonize the cellular defense in the host cells and involve in pathogenesis. ...To this end, we have performed structural modeling, small molecule screening, deconjugation assays to characterize and develop first-in-class inhibitors of P. falciparum, P. viv …
OTU proteases antagonize the cellular defense in the host cells and involve in pathogenesis. ...To this end, we have performed struct …
Otu and Rif1 Double Mutant Enables Analysis of Satellite DNA in Polytene Chromosomes of Ovarian Germ Cells in Drosophila melanogaster.
Kolesnikova TD, Nokhova AR, Shatskikh AS, Klenov MS, Zhimulev IF. Kolesnikova TD, et al. Dokl Biochem Biophys. 2023 Dec;513(Suppl 1):S87-S91. doi: 10.1134/S160767292360046X. Epub 2024 Feb 9. Dokl Biochem Biophys. 2023. PMID: 38337102
Here, we investigated the impact of the Rif1 mutation on heterochromatin in polytene chromosomes formed in ovarian germ cells due to the otu gene mutation. By the analysis of otu(11); Rif1(1) double mutants, we found that, in the presence of the Rif1 mutation, ovari …
Here, we investigated the impact of the Rif1 mutation on heterochromatin in polytene chromosomes formed in ovarian germ cells due to the …
3,278 results