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Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid.
J Gen Physiol. 2018 May 7;150(5):731-750. doi: 10.1085/jgp.201711965. Epub 2018 Apr 6.
J Gen Physiol. 2018.
PMID: 29626041
Free PMC article.
Drug-induced ion channel opening tuned by the voltage sensor charge profile.
Ottosson NE, Liin SI, Elinder F.
Ottosson NE, et al.
J Gen Physiol. 2014 Feb;143(2):173-82. doi: 10.1085/jgp.201311087. Epub 2014 Jan 13.
J Gen Physiol. 2014.
PMID: 24420769
Free PMC article.
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Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability.
Ottosson NE, Wu X, Nolting A, Karlsson U, Lund PE, Ruda K, Svensson S, Konradsson P, Elinder F.
Ottosson NE, et al.
Sci Rep. 2015 Aug 24;5:13278. doi: 10.1038/srep13278.
Sci Rep. 2015.
PMID: 26299574
Free PMC article.
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A drug pocket at the lipid bilayer-potassium channel interface.
Ottosson NE, Silverå Ejneby M, Wu X, Yazdi S, Konradsson P, Lindahl E, Elinder F.
Ottosson NE, et al.
Sci Adv. 2017 Oct 25;3(10):e1701099. doi: 10.1126/sciadv.1701099. eCollection 2017 Oct.
Sci Adv. 2017.
PMID: 29075666
Free PMC article.
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Resin-acid derivatives bind to multiple sites on the voltage-sensor domain of the Shaker potassium channel.
Silverå Ejneby M, Gromova A, Ottosson NE, Borg S, Estrada-Mondragón A, Yazdi S, Apostolakis P, Elinder F, Delemotte L.
Silverå Ejneby M, et al. Among authors: ottosson ne.
J Gen Physiol. 2021 Apr 5;153(4):e202012676. doi: 10.1085/jgp.202012676.
J Gen Physiol. 2021.
PMID: 33683319
Free PMC article.
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Synthetic resin acid derivatives selectively open the hKV 7.2/7.3 channel and prevent epileptic seizures.
Ottosson NE, Silverå Ejneby M, Wu X, Estrada-Mondragón A, Nilsson M, Karlsson U, Schupp M, Rognant S, Jepps TA, Konradsson P, Elinder F.
Ottosson NE, et al.
Epilepsia. 2021 Jul;62(7):1744-1758. doi: 10.1111/epi.16932. Epub 2021 Jun 4.
Epilepsia. 2021.
PMID: 34085706
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