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New technologies to study helminth development and host-parasite interactions.
Britton C, Laing R, McNeilly TN, Perez MG, Otto TD, Hildersley KA, Maizels RM, Devaney E, Gillan V. Britton C, et al. Among authors: otto td. Int J Parasitol. 2023 Jul;53(8):393-403. doi: 10.1016/j.ijpara.2022.11.012. Epub 2023 Mar 16. Int J Parasitol. 2023. PMID: 36931423 Free article. Review.
Phenotypic Screens Identify Genetic Factors Associated with Gametocyte Development in the Human Malaria Parasite Plasmodium falciparum.
Chawla J, Goldowitz I, Oberstaller J, Zhang M, Pires CV, Navarro F, Sollelis L, Wang CCQ, Seyfang A, Dvorin J, Otto TD, Rayner JC, Marti M, Adams JH. Chawla J, et al. Among authors: otto td. Microbiol Spectr. 2023 Jun 15;11(3):e0416422. doi: 10.1128/spectrum.04164-22. Epub 2023 May 8. Microbiol Spectr. 2023. PMID: 37154686 Free PMC article.
The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections.
Wichers-Misterek JS, Krumkamp R, Held J, von Thien H, Wittmann I, Höppner YD, Ruge JM, Moser K, Dara A, Strauss J, Esen M, Fendel R, Sulyok Z, Jeninga MD, Kremsner PG, Sim BKL, Hoffman SL, Duffy MF, Otto TD, Gilberger TW, Silva JC, Mordmüller B, Petter M, Bachmann A. Wichers-Misterek JS, et al. Among authors: otto td. PLoS Pathog. 2023 Jun 29;19(6):e1011468. doi: 10.1371/journal.ppat.1011468. eCollection 2023 Jun. PLoS Pathog. 2023. PMID: 37384799 Free PMC article.
Chemogenomic Profiling of a Plasmodium falciparum Transposon Mutant Library Reveals Shared Effects of Dihydroartemisinin and Bortezomib on Lipid Metabolism and Exported Proteins.
Pires CV, Oberstaller J, Wang C, Casandra D, Zhang M, Chawla J, Adapa SR, Otto TD, Ferdig MT, Rayner JC, Jiang RHY, Adams JH. Pires CV, et al. Among authors: otto td. Microbiol Spectr. 2023 Jun 15;11(3):e0501422. doi: 10.1128/spectrum.05014-22. Epub 2023 Apr 17. Microbiol Spectr. 2023. PMID: 37067430 Free PMC article.
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture.
Andradi-Brown C, Wichers-Misterek JS, von Thien H, Höppner YD, Scholz JAM, Hansson H, Filtenborg Hocke E, Gilberger TW, Duffy MF, Lavstsen T, Baum J, Otto TD, Cunnington AJ, Bachmann A. Andradi-Brown C, et al. Among authors: otto td. Elife. 2024 Jan 25;12:RP87726. doi: 10.7554/eLife.87726. Elife. 2024. PMID: 38270586 Free PMC article.
Sterile protection against P. vivax malaria by repeated blood stage infection in the Aotus monkey model.
Obaldía N 3rd, Da Silva Filho JL, Núñez M, Glass KA, Oulton T, Achcar F, Wirjanata G, Duraisingh M, Felgner P, Tetteh KK, Bozdech Z, Otto TD, Marti M. Obaldía N 3rd, et al. Among authors: otto td. Life Sci Alliance. 2023 Dec 29;7(3):e202302524. doi: 10.26508/lsa.202302524. Print 2024 Mar. Life Sci Alliance. 2023. PMID: 38158220 Free PMC article.
145 results