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Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer.
Abacha YZ, Forkuo AD, Gbedema SY, Mittal N, Ottilie S, Rocamora F, Winzeler EA, van Schalkwyk DA, Kelly JM, Taylor MC, Reader J, Birkholtz LM, Lisgarten DR, Cockcroft JK, Lisgarten JN, Palmer RA, Talbert RC, Shnyder SD, Wright CW. Abacha YZ, et al. Among authors: ottilie s. Front Pharmacol. 2022 Apr 26;13:875647. doi: 10.3389/fphar.2022.875647. eCollection 2022. Front Pharmacol. 2022. PMID: 35600849 Free PMC article.
Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor.
Goldgof GM, Durrant JD, Ottilie S, Vigil E, Allen KE, Gunawan F, Kostylev M, Henderson KA, Yang J, Schenken J, LaMonte GM, Manary MJ, Murao A, Nachon M, Murray R, Prescott M, McNamara CW, Slayman CW, Amaro RE, Suzuki Y, Winzeler EA. Goldgof GM, et al. Among authors: ottilie s. Sci Rep. 2016 Jun 13;6:27806. doi: 10.1038/srep27806. Sci Rep. 2016. PMID: 27291296 Free PMC article.
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.
LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, Gerwick WH, Ottilie S. LaMonte GM, et al. Among authors: ottilie s. J Med Chem. 2017 Aug 10;60(15):6721-6732. doi: 10.1021/acs.jmedchem.7b00671. Epub 2017 Jul 25. J Med Chem. 2017. PMID: 28696697 Free PMC article.
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome.
Xie SC, Gillett DL, Spillman NJ, Tsu C, Luth MR, Ottilie S, Duffy S, Gould AE, Hales P, Seager BA, Charron CL, Bruzzese F, Yang X, Zhao X, Huang SC, Hutton CA, Burrows JN, Winzeler EA, Avery VM, Dick LR, Tilley L. Xie SC, et al. Among authors: ottilie s. J Med Chem. 2018 Nov 21;61(22):10053-10066. doi: 10.1021/acs.jmedchem.8b01161. Epub 2018 Nov 7. J Med Chem. 2018. PMID: 30373366 Free PMC article.
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
Antonova-Koch Y, Meister S, Abraham M, Luth MR, Ottilie S, Lukens AK, Sakata-Kato T, Vanaerschot M, Owen E, Jado JC, Maher SP, Calla J, Plouffe D, Zhong Y, Chen K, Chaumeau V, Conway AJ, McNamara CW, Ibanez M, Gagaring K, Serrano FN, Eribez K, Taggard CM, Cheung AL, Lincoln C, Ambachew B, Rouillier M, Siegel D, Nosten F, Kyle DE, Gamo FJ, Zhou Y, Llinás M, Fidock DA, Wirth DF, Burrows J, Campo B, Winzeler EA. Antonova-Koch Y, et al. Among authors: ottilie s. Science. 2018 Dec 7;362(6419):eaat9446. doi: 10.1126/science.aat9446. Science. 2018. PMID: 30523084 Free PMC article.
Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents.
Fagundez C, Sellanes D, Peña S, Scarone L, Aguiar ACC, de Souza JO, Guido RVC, Stewart L, Yardley V, Ottilie S, Winzeler EA, Gamo FJ, Sanz LM, Serra GL. Fagundez C, et al. Among authors: ottilie s. ACS Med Chem Lett. 2018 Dec 26;10(1):137-141. doi: 10.1021/acsmedchemlett.8b00543. eCollection 2019 Jan 10. ACS Med Chem Lett. 2018. PMID: 30655961 Free PMC article.
In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.
Mandt REK, Lafuente-Monasterio MJ, Sakata-Kato T, Luth MR, Segura D, Pablos-Tanarro A, Viera S, Magan N, Ottilie S, Winzeler EA, Lukens AK, Gamo FJ, Wirth DF. Mandt REK, et al. Among authors: ottilie s. Sci Transl Med. 2019 Dec 4;11(521):eaav1636. doi: 10.1126/scitranslmed.aav1636. Sci Transl Med. 2019. PMID: 31801884 Free PMC article.
49 results