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AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery.
Abdelazeem H, Tu L, Thuillet R, Ottaviani M, Boulfrad A, Beck T, Senbel A, Mani S, Castier Y, Guyard A, Tran-Dinh A, El-Benna J, Longrois D, Silverstein AM, Guignabert C, Norel X. Abdelazeem H, et al. Among authors: ottaviani m. Eur J Pharmacol. 2023 May 5;946:175579. doi: 10.1016/j.ejphar.2023.175579. Epub 2023 Mar 11. Eur J Pharmacol. 2023. PMID: 36914083
Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models.
Orvain C, Cauvet A, Prudent A, Guignabert C, Thuillet R, Ottaviani M, Tu L, Duhalde F, Nicco C, Batteux F, Avouac J, Wang N, Seaberg MA, Dillon SR, Allanore Y. Orvain C, et al. Among authors: ottaviani m. Arthritis Res Ther. 2022 Jan 5;24(1):13. doi: 10.1186/s13075-021-02709-2. Arthritis Res Ther. 2022. PMID: 34986869 Free PMC article.
Driving Role of Interleukin-2-Related Regulatory CD4+ T Cell Deficiency in the Development of Lung Fibrosis and Vascular Remodeling in a Mouse Model of Systemic Sclerosis.
Frantz C, Cauvet A, Durand A, Gonzalez V, Pierre R, Do Cruzeiro M, Bailly K, Andrieu M, Orvain C, Avouac J, Ottaviani M, Thuillet R, Tu L, Guignabert C, Lucas B, Auffray C, Allanore Y. Frantz C, et al. Among authors: ottaviani m. Arthritis Rheumatol. 2022 Aug;74(8):1387-1398. doi: 10.1002/art.42111. Epub 2022 Jun 28. Arthritis Rheumatol. 2022. PMID: 35255201
Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension.
Guignabert C, Savale L, Boucly A, Thuillet R, Tu L, Ottaviani M, Rhodes CJ, De Groote P, Prévot G, Bergot E, Bourdin A, Howard LS, Fadel E, Beurnier A, Roche A, Jevnikar M, Jaïs X, Montani D, Wilkins MR, Sitbon O, Humbert M. Guignabert C, et al. Among authors: ottaviani m. Circulation. 2023 Jun 13;147(24):1809-1822. doi: 10.1161/CIRCULATIONAHA.122.061501. Epub 2023 Apr 25. Circulation. 2023. PMID: 37096577
288 results