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A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication.
Han H, Gracia AV, Røise JJ, Boike L, Leon K, Schulze-Gahmen U, Stentzel MR, Bajaj T, Chen D, Li IC, He M, Behrouzi K, Khodabakhshi Z, Nomura DK, Mofrad MRK, Kumar GR, Ott M, Murthy N. Han H, et al. Among authors: ott m. RSC Adv. 2023 Apr 4;13(16):10636-10641. doi: 10.1039/d3ra00426k. eCollection 2023 Apr 3. RSC Adv. 2023. PMID: 37025664 Free PMC article.
Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation.
Deng X, Garcia-Knight MA, Khalid MM, Servellita V, Wang C, Morris MK, Sotomayor-González A, Glasner DR, Reyes KR, Gliwa AS, Reddy NP, Martin CSS, Federman S, Cheng J, Balcerek J, Taylor J, Streithorst JA, Miller S, Kumar GR, Sreekumar B, Chen PY, Schulze-Gahmen U, Taha TY, Hayashi J, Simoneau CR, McMahon S, Lidsky PV, Xiao Y, Hemarajata P, Green NM, Espinosa A, Kath C, Haw M, Bell J, Hacker JK, Hanson C, Wadford DA, Anaya C, Ferguson D, Lareau LF, Frankino PA, Shivram H, Wyman SK, Ott M, Andino R, Chiu CY. Deng X, et al. Among authors: ott m. medRxiv [Preprint]. 2021 Mar 9:2021.03.07.21252647. doi: 10.1101/2021.03.07.21252647. medRxiv. 2021. PMID: 33758899 Free PMC article. Updated. Preprint.
Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein.
Weinberg ZY, Hilburger CE, Kim M, Cao L, Khalid M, Elmes S, Diwanji D, Hernandez E, Lopez J, Schaefer K, Smith AM, Zhou F; QCRG Structural Biology Consortium; Kumar GR, Ott M, Baker D, El-Samad H. Weinberg ZY, et al. Among authors: ott m. bioRxiv [Preprint]. 2021 Apr 20:2021.04.20.440678. doi: 10.1101/2021.04.20.440678. bioRxiv. 2021. PMID: 33907743 Free PMC article. Preprint.
Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles.
Syed AM, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Taha TY, Tabata T, Chen IP, Ott M, Doudna JA. Syed AM, et al. Among authors: ott m. medRxiv [Preprint]. 2022 Jan 2:2021.12.20.21268048. doi: 10.1101/2021.12.20.21268048. medRxiv. 2022. PMID: 34981067 Free PMC article. Updated. Preprint.
Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication.
Bajaj T, Wehri E, Suryawanshi RK, King E, Pardeshi KS, Behrouzi K, Khodabakhshi Z, Schulze-Gahmen U, Kumar GR, Mofrad MRK, Nomura DK, Ott M, Schaletzky J, Murthy N. Bajaj T, et al. Among authors: ott m. RSC Adv. 2023 Jun 12;13(26):17667-17677. doi: 10.1039/d3ra01915b. eCollection 2023 Jun 9. RSC Adv. 2023. PMID: 37312993 Free PMC article.
Accelerated RNA detection using tandem CRISPR nucleases.
Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, de León Derby MD, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, Fozouni P, Shu J, Stephens SI, Kumar GR, Zhao C, Mok A, Iavarone AT, Escajeda AM, McIntosh R, Kim SE, Dugan EJ; IGI Testing Consortium; Pollard KS, Tan MX, Ott M, Fletcher DA, Lareau LF, Hsu PD, Savage DF, Doudna JA. Liu TY, et al. Among authors: ott m. medRxiv [Preprint]. 2021 Mar 24:2021.03.19.21253328. doi: 10.1101/2021.03.19.21253328. medRxiv. 2021. PMID: 33791736 Free PMC article. Updated. Preprint.
Mild SARS-CoV-2 infection results in long-lasting microbiota instability.
Upadhyay V, Suryawanshi R, Tasoff P, McCavitt-Malvido M, Kumar GR, Murray VW, Noecker C, Bisanz JE, Hswen Y, Ha C, Sreekumar B, Chen IP, Lynch SV, Ott M, Lee S, Turnbaugh PJ. Upadhyay V, et al. Among authors: ott m. bioRxiv [Preprint]. 2022 Dec 8:2022.12.07.519508. doi: 10.1101/2022.12.07.519508. bioRxiv. 2022. PMID: 36523400 Free PMC article. Updated. Preprint.
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo.
Taha TY, Suryawanshi RK, Chen IP, Correy GJ, O'Leary PC, Jogalekar MP, McCavitt-Malvido M, Diolaiti ME, Kimmerly GR, Tsou CL, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M. Taha TY, et al. Among authors: ott m. bioRxiv [Preprint]. 2023 May 10:2023.04.18.537104. doi: 10.1101/2023.04.18.537104. bioRxiv. 2023. PMID: 37131711 Free PMC article. Updated. Preprint.
1,244 results