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ALDH1A3 Coordinates Metabolism With Gene Regulation in Pulmonary Arterial Hypertension.
Li D, Shao NY, Moonen JR, Zhao Z, Shi M, Otsuki S, Wang L, Nguyen T, Yan E, Marciano DP, Contrepois K, Li CG, Wu JC, Snyder MP, Rabinovitch M. Li D, et al. Among authors: otsuki s. Circulation. 2021 May 25;143(21):2074-2090. doi: 10.1161/CIRCULATIONAHA.120.048845. Epub 2021 Mar 25. Circulation. 2021. PMID: 33764154 Free PMC article.
Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension.
Taylor S, Isobe S, Cao A, Contrepois K, Benayoun BA, Jiang L, Wang L, Melemenidis S, Ozen MO, Otsuki S, Shinohara T, Sweatt AJ, Kaplan J, Moonen JR, Marciano DP, Gu M, Miyagawa K, Hayes B, Sierra RG, Kupitz CJ, Del Rosario PA, Hsi A, Thompson AAR, Ariza ME, Demirci U, Zamanian RT, Haddad F, Nicolls MR, Snyder MP, Rabinovitch M. Taylor S, et al. Among authors: otsuki s. Am J Respir Crit Care Med. 2022 Oct 15;206(8):1019-1034. doi: 10.1164/rccm.202102-0446OC. Am J Respir Crit Care Med. 2022. PMID: 35696338 Free PMC article.
Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension.
Isobe S, Nair RV, Kang HY, Wang L, Moonen JR, Shinohara T, Cao A, Taylor S, Otsuki S, Marciano DP, Harper RL, Adil MS, Zhang C, Lago-Docampo M, Körbelin J, Engreitz JM, Snyder MP, Rabinovitch M. Isobe S, et al. Among authors: otsuki s. Nat Commun. 2023 Nov 21;14(1):7578. doi: 10.1038/s41467-023-43039-y. Nat Commun. 2023. PMID: 37989727 Free PMC article.
Potential contribution of phenotypically modulated smooth muscle cells and related inflammation in the development of experimental obstructive pulmonary vasculopathy in rats.
Otsuki S, Sawada H, Yodoya N, Shinohara T, Kato T, Ohashi H, Zhang E, Imanaka-Yoshida K, Shimpo H, Maruyama K, Komada Y, Mitani Y. Otsuki S, et al. PLoS One. 2015 Feb 25;10(2):e0118655. doi: 10.1371/journal.pone.0118655. eCollection 2015. PLoS One. 2015. PMID: 25714834 Free PMC article.
A non-selective endothelin receptor antagonist bosentan modulates kinetics of bone marrow-derived cells in ameliorating pulmonary hypertension in mice.
Kato T, Mitani Y, Masuya M, Maruyama J, Sawada H, Ohashi H, Ikeyama Y, Otsuki S, Yodoya N, Shinohara T, Miyata E, Zhang E, Katayama N, Shimpo H, Maruyama K, Komada Y, Hirayama M. Kato T, et al. Among authors: otsuki s. Pulm Circ. 2020 May 14;10(2):2045894020919355. doi: 10.1177/2045894020919355. eCollection 2020 Apr-Jun. Pulm Circ. 2020. PMID: 32489640 Free PMC article.
Perinatal hypoxia aggravates occlusive pulmonary vasculopathy in SU5416/hypoxia-treated rats later in life.
Oshita H, Sawada H, Mitani Y, Tsuboya N, Kabwe JC, Maruyama J, Yusuf A, Ito H, Okamoto R, Otsuki S, Yodoya N, Ohashi H, Oya K, Kobayashi Y, Kobayashi I, Dohi K, Nishimura Y, Saitoh S, Maruyama K, Hirayama M. Oshita H, et al. Among authors: otsuki s. Am J Physiol Lung Cell Mol Physiol. 2022 Aug 1;323(2):L178-L192. doi: 10.1152/ajplung.00422.2021. Epub 2022 Jun 28. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35762603 Free article.
Macitentan reverses early obstructive pulmonary vasculopathy in rats: early intervention in overcoming the survivin-mediated resistance to apoptosis.
Shinohara T, Sawada H, Otsuki S, Yodoya N, Kato T, Ohashi H, Zhang E, Saitoh S, Shimpo H, Maruyama K, Komada Y, Mitani Y. Shinohara T, et al. Among authors: otsuki s. Am J Physiol Lung Cell Mol Physiol. 2015 Mar 15;308(6):L523-38. doi: 10.1152/ajplung.00129.2014. Epub 2014 Dec 24. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25539851 Free article.
CRISPR-mediated Bmpr2 point mutation exacerbates late pulmonary vasculopathy and reduces survival in rats with experimental pulmonary hypertension.
Kabwe JC, Sawada H, Mitani Y, Oshita H, Tsuboya N, Zhang E, Maruyama J, Miyasaka Y, Ko H, Oya K, Ito H, Yodoya N, Otsuki S, Ohashi H, Okamoto R, Dohi K, Nishimura Y, Mashimo T, Hirayama M, Maruyama K. Kabwe JC, et al. Among authors: otsuki s. Respir Res. 2022 Apr 8;23(1):87. doi: 10.1186/s12931-022-02005-w. Respir Res. 2022. PMID: 35395852 Free PMC article.
530 results