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European Medicinal Chemistry Leaders in Industry (EMCL) - On the Status and Future of Medicinal Chemistry Research in Europe.
Ali A, Bauser M, Bertrand S, Blackaby W, Boss C, Bossart M, Hall A, Binch H, Czechtizky W, Gijsen H, Haning H, Hartung IV, Kilburn P, Lassalle G, Lücking U, Mack J, Missbach M, Otsomaa L, Torrens A, Wagner M, Walter M, Weinstabl H, van Hijfte L, von Nussbaum F. Ali A, et al. Among authors: otsomaa l. ChemMedChem. 2023 Jul 3;18(13):e202300127. doi: 10.1002/cmdc.202300127. Epub 2023 Jun 5. ChemMedChem. 2023. PMID: 37276375 Review.
Discovery and characterization of ORM-11372, a novel inhibitor of the sodium-calcium exchanger with positive inotropic activity.
Otsomaa L, Levijoki J, Wohlfahrt G, Chapman H, Koivisto AP, Syrjänen K, Koskelainen T, Peltokorpi SE, Finckenberg P, Heikkilä A, Abi-Gerges N, Ghetti A, Miller PE, Page G, Mervaala E, Nagy N, Kohajda Z, Jost N, Virág L, Varró A, Papp JG. Otsomaa L, et al. Br J Pharmacol. 2020 Dec;177(24):5534-5554. doi: 10.1111/bph.15257. Epub 2020 Nov 10. Br J Pharmacol. 2020. PMID: 32959887 Free PMC article.
Long-term effects of Na+ /Ca2+ exchanger inhibition with ORM-11035 improves cardiac function and remodelling without lowering blood pressure in a model of heart failure with preserved ejection fraction.
Primessnig U, Bracic T, Levijoki J, Otsomaa L, Pollesello P, Falcke M, Pieske B, Heinzel FR. Primessnig U, et al. Among authors: otsomaa l. Eur J Heart Fail. 2019 Dec;21(12):1543-1552. doi: 10.1002/ejhf.1619. Epub 2019 Nov 24. Eur J Heart Fail. 2019. PMID: 31762174 Free article.
Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes.
Oravecz K, Kormos A, Gruber A, Márton Z, Kohajda Z, Mirzaei L, Jost N, Levijoki J, Pollesello P, Koskelainen T, Otsomaa L, Tóth A, Papp JG, Nánási PP, Antoons G, Varró A, Acsai K, Nagy N. Oravecz K, et al. Among authors: otsomaa l. Eur J Pharmacol. 2018 Jan 5;818:278-286. doi: 10.1016/j.ejphar.2017.10.039. Epub 2017 Oct 21. Eur J Pharmacol. 2018. PMID: 29066415 Free article.
The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments.
Kohajda Z, Farkas-Morvay N, Jost N, Nagy N, Geramipour A, Horváth A, Varga RS, Hornyik T, Corici C, Acsai K, Horváth B, Prorok J, Ördög B, Déri S, Tóth D, Levijoki J, Pollesello P, Koskelainen T, Otsomaa L, Tóth A, Baczkó I, Leprán I, Nánási PP, Papp JG, Varró A, Virág L. Kohajda Z, et al. Among authors: otsomaa l. PLoS One. 2016 Nov 10;11(11):e0166041. doi: 10.1371/journal.pone.0166041. eCollection 2016. PLoS One. 2016. PMID: 27832106 Free PMC article.
Synthesis of 6-deoxyamino sugars.
Otsomaa LA, Koskinen AM. Otsomaa LA, et al. Fortschr Chem Org Naturst. 1998;74:197-263. doi: 10.1007/978-3-7091-6496-9_2. Fortschr Chem Org Naturst. 1998. PMID: 9597942 Review. No abstract available.