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Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy.
Beaulieu ME, Jauset T, Massó-Vallés D, Martínez-Martín S, Rahl P, Maltais L, Zacarias-Fluck MF, Casacuberta-Serra S, Serrano Del Pozo E, Fiore C, Foradada L, Cano VC, Sánchez-Hervás M, Guenther M, Romero Sanz E, Oteo M, Tremblay C, Martín G, Letourneau D, Montagne M, Morcillo Alonso MÁ, Whitfield JR, Lavigne P, Soucek L. Beaulieu ME, et al. Among authors: oteo m. Sci Transl Med. 2019 Mar 20;11(484):eaar5012. doi: 10.1126/scitranslmed.aar5012. Sci Transl Med. 2019. PMID: 30894502 Free PMC article.
Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes.
Lázaro S, Pérez-Crespo M, Lorz C, Bernardini A, Oteo M, Enguita AB, Romero E, Hernández P, Tomás L, Morcillo MÁ, Paramio JM, Santos M. Lázaro S, et al. Among authors: oteo m. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22300-22306. doi: 10.1073/pnas.1821745116. Epub 2019 Oct 14. Proc Natl Acad Sci U S A. 2019. PMID: 31611390 Free PMC article.
An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity.
Compte M, Harwood SL, Erce-Llamazares A, Tapia-Galisteo A, Romero E, Ferrer I, Garrido-Martin EM, Enguita AB, Ochoa MC, Blanco B, Oteo M, Merino N, Nehme-Álvarez D, Hangiu O, Domínguez-Alonso C, Zonca M, Ramírez-Fernández A, Blanco FJ, Morcillo MA, Muñoz IG, Melero I, Rodriguez-Peralto JL, Paz-Ares L, Sanz L, Alvarez-Vallina L. Compte M, et al. Among authors: oteo m. Clin Cancer Res. 2021 Jun 1;27(11):3167-3177. doi: 10.1158/1078-0432.CCR-20-4625. Epub 2021 Mar 30. Clin Cancer Res. 2021. PMID: 33785484
Adipocyte MTERF4 regulates non-shivering adaptive thermogenesis and sympathetic-dependent glucose homeostasis.
Castillo A, Vilà M, Pedriza I, Pardo R, Cámara Y, Martín E, Beiroa D, Torres-Torronteras J, Oteo M, Morcillo MA, Martí R, Simó R, Nogueiras R, Villena JA. Castillo A, et al. Among authors: oteo m. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1298-1312. doi: 10.1016/j.bbadis.2019.01.025. Epub 2019 Jan 26. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30690068 Free article.
In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer.
Santos M, Martínez-Fernández M, Dueñas M, García-Escudero R, Alfaya B, Villacampa F, Saiz-Ladera C, Costa C, Oteo M, Duarte J, Martínez V, Gómez-Rodriguez MJ, Martín ML, Fernández M, Viatour P, Morcillo MA, Sage J, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Paramio JM. Santos M, et al. Among authors: oteo m. Cancer Res. 2014 Nov 15;74(22):6565-6577. doi: 10.1158/0008-5472.CAN-14-1218. Epub 2014 Sep 24. Cancer Res. 2014. PMID: 25252918 Free PMC article.
Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas.
de Lucas AG, Schuhmacher AJ, Oteo M, Romero E, Cámara JA, de Martino A, Arroyo AG, Morcillo MÁ, Squatrito M, Martinez-Torrecuadrada JL, Mulero F. de Lucas AG, et al. Among authors: oteo m. PLoS One. 2016 Jul 27;11(7):e0158634. doi: 10.1371/journal.pone.0158634. eCollection 2016. PLoS One. 2016. PMID: 27462980 Free PMC article.
A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.
Calvete O, Varro A, Pritchard DM, Barroso A, Oteo M, Morcillo MÁ, Vargiu P, Dodd S, Garcia M, Reyes J, Ortega S, Benitez J. Calvete O, et al. Among authors: oteo m. Dis Model Mech. 2016 Sep 1;9(9):975-84. doi: 10.1242/dmm.025890. Epub 2016 Aug 4. Dis Model Mech. 2016. PMID: 27491072 Free PMC article.
30 results