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Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
Eur J Med Chem. 2023 Nov 5;259:115685. doi: 10.1016/j.ejmech.2023.115685. Epub 2023 Jul 26.
Eur J Med Chem. 2023.
PMID: 37567057
Free article.
The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors.
Otava T, Šála M, Li F, Fanfrlík J, Devkota K, Perveen S, Chau I, Pakarian P, Hobza P, Vedadi M, Boura E, Nencka R.
Otava T, et al.
ACS Infect Dis. 2021 Aug 13;7(8):2214-2220. doi: 10.1021/acsinfecdis.1c00131. Epub 2021 Jun 21.
ACS Infect Dis. 2021.
PMID: 34152728
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Coronaviral RNA-methyltransferases: function, structure and inhibition.
Nencka R, Silhan J, Klima M, Otava T, Kocek H, Krafcikova P, Boura E.
Nencka R, et al. Among authors: otava t.
Nucleic Acids Res. 2022 Jan 25;50(2):635-650. doi: 10.1093/nar/gkab1279.
Nucleic Acids Res. 2022.
PMID: 35018474
Free PMC article.
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Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Silhan J, Klima M, Otava T, Skvara P, Chalupska D, Chalupsky K, Kozic J, Nencka R, Boura E.
Silhan J, et al. Among authors: otava t.
Nat Commun. 2023 Apr 20;14(1):2259. doi: 10.1038/s41467-023-38019-1.
Nat Commun. 2023.
PMID: 37080993
Free PMC article.
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Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors.
Štefek M, Chalupská D, Chalupský K, Zgarbová M, Dvořáková A, Krafčíková P, Li ASM, Šála M, Dejmek M, Otava T, Chaloupecká E, Kozák J, Kozic J, Vedadi M, Weber J, Mertlíková-Kaiserová H, Nencka R.
Štefek M, et al. Among authors: otava t.
ACS Omega. 2023 Jul 21;8(30):27410-27418. doi: 10.1021/acsomega.3c02815. eCollection 2023 Aug 1.
ACS Omega. 2023.
PMID: 37546609
Free PMC article.
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Inhibitors of mpox VP39 2'-O methyltransferase efficiently inhibit the monkeypox virus.
Zgarbová M, Otava T, Silhan J, Nencka R, Weber J, Boura E.
Zgarbová M, et al. Among authors: otava t.
Antiviral Res. 2023 Oct;218:105714. doi: 10.1016/j.antiviral.2023.105714. Epub 2023 Sep 9.
Antiviral Res. 2023.
PMID: 37689311
Free article.
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