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KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels.
Tsuji S, Otani C, Horie T, Watanabe S, Baba O, Sowa N, Ide Y, Kashiwa A, Makiyama T, Imai H, Nakashima Y, Yamasaki T, Xu S, Matsushita K, Suzuki K, Zou F, Kume E, Hasegawa K, Kimura T, Kakizuka A, Ono K. Tsuji S, et al. Among authors: otani c. Biomed Pharmacother. 2024 Jan;170:115850. doi: 10.1016/j.biopha.2023.115850. Epub 2023 Dec 12. Biomed Pharmacother. 2024. PMID: 38091636 Free article.
Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction.
Ide Y, Horie T, Saito N, Watanabe S, Otani C, Miyasaka Y, Kuwabara Y, Nishino T, Nakao T, Nishiga M, Nishi H, Nakashima Y, Nakazeki F, Koyama S, Kimura M, Tsuji S, Rodriguez RR, Xu S, Yamasaki T, Watanabe T, Yamamoto M, Yanagita M, Kimura T, Kakizuka A, Ono K. Ide Y, et al. Among authors: otani c. JACC Basic Transl Sci. 2019 Oct 28;4(6):701-714. doi: 10.1016/j.jacbts.2019.06.001. eCollection 2019 Oct. JACC Basic Transl Sci. 2019. PMID: 31709319 Free PMC article.
Identification of Differential Roles of MicroRNA-33a and -33b During Atherosclerosis Progression With Genetically Modified Mice.
Koyama S, Horie T, Nishino T, Baba O, Sowa N, Miyasaka Y, Kuwabara Y, Nakao T, Nishiga M, Nishi H, Nakashima Y, Nakazeki F, Ide Y, Kimura M, Tsuji S, Ruiz Rodriguez R, Xu S, Yamasaki T, Otani C, Watanabe T, Nakamura T, Hasegawa K, Kimura T, Ono K. Koyama S, et al. Among authors: otani c. J Am Heart Assoc. 2019 Jul 2;8(13):e012609. doi: 10.1161/JAHA.119.012609. Epub 2019 Jun 27. J Am Heart Assoc. 2019. PMID: 31242815 Free PMC article.
Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis.
Miyagawa S, Horie T, Nishino T, Koyama S, Watanabe T, Baba O, Yamasaki T, Sowa N, Otani C, Matsushita K, Kojima H, Kimura M, Nakashima Y, Obika S, Kasahara Y, Kotera J, Oka K, Fujita R, Sasaki T, Takemiya A, Hasegawa K, Kimura T, Ono K. Miyagawa S, et al. Among authors: otani c. Life Sci Alliance. 2023 Jun 1;6(8):e202301902. doi: 10.26508/lsa.202301902. Print 2023 Aug. Life Sci Alliance. 2023. PMID: 37263777 Free PMC article.
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity.
Horie T, Nakao T, Miyasaka Y, Nishino T, Matsumura S, Nakazeki F, Ide Y, Kimura M, Tsuji S, Rodriguez RR, Watanabe T, Yamasaki T, Xu S, Otani C, Miyagawa S, Matsushita K, Sowa N, Omori A, Tanaka J, Nishimura C, Nishiga M, Kuwabara Y, Baba O, Watanabe S, Nishi H, Nakashima Y, Picciotto MR, Inoue H, Watanabe D, Nakamura K, Sasaki T, Kimura T, Ono K. Horie T, et al. Among authors: otani c. Nat Commun. 2021 Feb 16;12(1):843. doi: 10.1038/s41467-021-21107-5. Nat Commun. 2021. PMID: 33594062 Free PMC article.
THz irradiation inhibits cell division by affecting actin dynamics.
Yamazaki S, Ueno Y, Hosoki R, Saito T, Idehara T, Yamaguchi Y, Otani C, Ogawa Y, Harata M, Hoshina H. Yamazaki S, et al. Among authors: otani c. PLoS One. 2021 Aug 2;16(8):e0248381. doi: 10.1371/journal.pone.0248381. eCollection 2021. PLoS One. 2021. PMID: 34339441 Free PMC article.
42 results