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Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment.
Wunderlich CM, Ackermann PJ, Ostermann AL, Adams-Quack P, Vogt MC, Tran ML, Nikolajev A, Waisman A, Garbers C, Theurich S, Mauer J, Hövelmeyer N, Wunderlich FT. Wunderlich CM, et al. Among authors: ostermann al. Nat Commun. 2018 Apr 25;9(1):1646. doi: 10.1038/s41467-018-03773-0. Nat Commun. 2018. PMID: 29695802 Free PMC article.
Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer.
Ostermann AL, Wunderlich CM, Schneiders L, Vogt MC, Woeste MA, Belgardt BF, Niessen CM, Martiny B, Schauss AC, Frommolt P, Nikolaev A, Hövelmeyer N, Sears RC, Koch PJ, Günzel D, Brüning JC, Wunderlich FT. Ostermann AL, et al. Nat Metab. 2019 Mar;1(3):371-389. doi: 10.1038/s42255-019-0037-8. Epub 2019 Mar 4. Nat Metab. 2019. PMID: 32694718