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DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma.
Strubel A, Münick P, Hartmann O, Chaikuad A, Dreier B, Schaefer JV, Gebel J, Osterburg C, Tuppi M, Schäfer B, Buck V, Rosenfeldt M, Knapp S, Plückthun A, Diefenbacher ME, Dötsch V. Strubel A, et al. Among authors: osterburg c. Cell Death Dis. 2023 Oct 12;14(10):674. doi: 10.1038/s41419-023-06213-0. Cell Death Dis. 2023. PMID: 37828008 Free PMC article.
Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.
Gebel J, Luh LM, Coutandin D, Osterburg C, Löhr F, Schäfer B, Frombach AS, Sumyk M, Buchner L, Krojer T, Salah E, Mathea S, Güntert P, Knapp S, Dötsch V. Gebel J, et al. Among authors: osterburg c. Cell Death Differ. 2016 Dec;23(12):1930-1940. doi: 10.1038/cdd.2016.83. Epub 2016 Oct 7. Cell Death Differ. 2016. PMID: 27716744 Free PMC article.
Structural diversity of p63 and p73 isoforms.
Osterburg C, Dötsch V. Osterburg C, et al. Cell Death Differ. 2022 May;29(5):921-937. doi: 10.1038/s41418-022-00975-4. Epub 2022 Mar 21. Cell Death Differ. 2022. PMID: 35314772 Free PMC article. Review.
Designed Ankyrin Repeat Proteins as a tool box for analyzing p63.
Strubel A, Münick P, Chaikuad A, Dreier B, Schaefer J, Gebel J, Osterburg C, Tuppi M, Schäfer B, Knapp S, Plückthun A, Dötsch V. Strubel A, et al. Among authors: osterburg c. Cell Death Differ. 2022 Dec;29(12):2445-2458. doi: 10.1038/s41418-022-01030-y. Epub 2022 Jun 18. Cell Death Differ. 2022. PMID: 35717504 Free PMC article.
Control mechanisms in germ cells mediated by p53 family proteins.
Gebel J, Tuppi M, Krauskopf K, Coutandin D, Pitzius S, Kehrloesser S, Osterburg C, Dötsch V. Gebel J, et al. Among authors: osterburg c. J Cell Sci. 2017 Aug 9:jcs.204859. doi: 10.1242/jcs.204859. Online ahead of print. J Cell Sci. 2017. PMID: 28794013 Review.
Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome.
Russo C, Osterburg C, Sirico A, Antonini D, Ambrosio R, Würz JM, Rinnenthal J, Ferniani M, Kehrloesser S, Schäfer B, Güntert P, Sinha S, Dötsch V, Missero C. Russo C, et al. Among authors: osterburg c. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E906-E915. doi: 10.1073/pnas.1713773115. Epub 2018 Jan 16. Proc Natl Acad Sci U S A. 2018. PMID: 29339502 Free PMC article.
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