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Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification.
Carbone D, Vestuto V, Ferraro MR, Ciaglia T, Pecoraro C, Sommella E, Cascioferro S, Salviati E, Novi S, Tecce MF, Amodio G, Iraci N, Cirrincione G, Campiglia P, Diana P, Bertamino A, Parrino B, Ostacolo C. Carbone D, et al. Among authors: ostacolo c. Eur J Med Chem. 2022 Apr 15;234:114233. doi: 10.1016/j.ejmech.2022.114233. Epub 2022 Mar 6. Eur J Med Chem. 2022. PMID: 35286926
Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators.
Bertamino A, Ostacolo C, Ambrosino P, Musella S, Di Sarno V, Ciaglia T, Soldovieri MV, Iraci N, Fernandez Carvajal A, de la Torre-Martinez R, Ferrer-Montiel A, Gonzalez Muniz R, Novellino E, Taglialatela M, Campiglia P, Gomez-Monterrey I. Bertamino A, et al. Among authors: ostacolo c. J Med Chem. 2016 Mar 10;59(5):2179-91. doi: 10.1021/acs.jmedchem.5b01914. Epub 2016 Feb 17. J Med Chem. 2016. PMID: 26847872 Free article.
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme.
Lauro G, Tortorella P, Bertamino A, Ostacolo C, Koeberle A, Fischer K, Bruno I, Terracciano S, Gomez-Monterrey IM, Tauro M, Loiodice F, Novellino E, Riccio R, Werz O, Campiglia P, Bifulco G. Lauro G, et al. Among authors: ostacolo c. ChemMedChem. 2016 Mar 17;11(6):612-9. doi: 10.1002/cmdc.201500598. Epub 2016 Feb 24. ChemMedChem. 2016. PMID: 26915684
Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor.
Musella S, di Sarno V, Ciaglia T, Sala M, Spensiero A, Scala MC, Ostacolo C, Andrei G, Balzarini J, Snoeck R, Novellino E, Campiglia P, Bertamino A, Gomez-Monterrey IM. Musella S, et al. Among authors: ostacolo c. Eur J Med Chem. 2016 Nov 29;124:773-781. doi: 10.1016/j.ejmech.2016.09.014. Epub 2016 Sep 7. Eur J Med Chem. 2016. PMID: 27639368 Free PMC article.
Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening.
Lauro G, Manfra M, Pedatella S, Fischer K, Cantone V, Terracciano S, Bertamino A, Ostacolo C, Gomez-Monterrey I, De Nisco M, Riccio R, Novellino E, Werz O, Campiglia P, Bifulco G. Lauro G, et al. Among authors: ostacolo c. Eur J Med Chem. 2017 Jan 5;125:278-287. doi: 10.1016/j.ejmech.2016.09.042. Epub 2016 Sep 14. Eur J Med Chem. 2017. PMID: 27688183
Development of an improved online comprehensive hydrophilic interaction chromatography × reversed-phase ultra-high-pressure liquid chromatography platform for complex multiclass polyphenolic sample analysis.
Sommella E, Ismail OH, Pagano F, Pepe G, Ostacolo C, Mazzoccanti G, Russo M, Novellino E, Gasparrini F, Campiglia P. Sommella E, et al. Among authors: ostacolo c. J Sep Sci. 2017 May;40(10):2188-2197. doi: 10.1002/jssc.201700134. Epub 2017 Apr 19. J Sep Sci. 2017. PMID: 28349602
65 results