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A phenotypic drug discovery study on thienodiazepine derivatives as inhibitors of T cell proliferation induced by CD28 co-stimulation leads to the discovery of a first bromodomain inhibitor.
Endo J, Hikawa H, Hamada M, Ishibuchi S, Fujie N, Sugiyama N, Tanaka M, Kobayashi H, Sugahara K, Oshita K, Iwata K, Ooike S, Murata M, Sumichika H, Chiba K, Adachi K. Endo J, et al. Among authors: oshita k. Bioorg Med Chem Lett. 2016 Mar 1;26(5):1365-70. doi: 10.1016/j.bmcl.2016.01.084. Epub 2016 Feb 2. Bioorg Med Chem Lett. 2016. PMID: 26869194
Immunosuppressive activity of FTY720, sphingosine 1-phosphate receptor agonist: II. Effect of FTY720 and FTY720-phosphate on host-versus-graft and graft-versus-host reaction in mice.
Kataoka H, Ohtsuki M, Shimano K, Mochizuki S, Oshita K, Murata M, Sugahara K, Sato N, Hoshino Y, Chiba K. Kataoka H, et al. Among authors: oshita k. Transplant Proc. 2005 Jan-Feb;37(1):107-9. doi: 10.1016/j.transproceed.2004.12.287. Transplant Proc. 2005. PMID: 15808562 No abstract available.
C5a promotes migration, proliferation, and vessel formation in endothelial cells.
Kurihara R, Yamaoka K, Sawamukai N, Shimajiri S, Oshita K, Yukawa S, Tokunaga M, Iwata S, Saito K, Chiba K, Tanaka Y. Kurihara R, et al. Among authors: oshita k. Inflamm Res. 2010 Aug;59(8):659-66. doi: 10.1007/s00011-010-0178-4. Epub 2010 Mar 9. Inflamm Res. 2010. PMID: 20217457 Free PMC article.
176 results