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Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling.
Kamdem N, Roske Y, Kovalskyy D, Platonov MO, Balinskyi O, Kreuchwig A, Saupe J, Fang L, Diehl A, Schmieder P, Krause G, Rademann J, Heinemann U, Birchmeier W, Oschkinat H. Kamdem N, et al. Among authors: oschkinat h. Magn Reson (Gott). 2021 Jun 2;2(1):355-374. doi: 10.5194/mr-2-355-2021. eCollection 2021. Magn Reson (Gott). 2021. PMID: 37904770 Free PMC article.
Small-molecule inhibitors of AF6 PDZ-mediated protein-protein interactions.
Vargas C, Radziwill G, Krause G, Diehl A, Keller S, Kamdem N, Czekelius C, Kreuchwig A, Schmieder P, Doyle D, Moelling K, Hagen V, Schade M, Oschkinat H. Vargas C, et al. Among authors: oschkinat h. ChemMedChem. 2014 Jul;9(7):1458-62. doi: 10.1002/cmdc.201300553. Epub 2014 Mar 25. ChemMedChem. 2014. PMID: 24668962
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone M, Müller M, Chiha S, Ren J, Albat D, Soicke A, Dohmen S, Klein M, Bruns J, van Dinther M, Opitz R, Lindemann P, Beerbaum M, Motzny K, Roske Y, Schmieder P, Volkmer R, Nazaré M, Heinemann U, Oschkinat H, Ten Dijke P, Schmalz HG, Kühne R. Barone M, et al. Among authors: oschkinat h. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29684-29690. doi: 10.1073/pnas.2007213117. Epub 2020 Nov 12. Proc Natl Acad Sci U S A. 2020. PMID: 33184177 Free PMC article.
TapA acts as specific chaperone in TasA filament formation by strand complementation.
Roske Y, Lindemann F, Diehl A, Cremer N, Higman VA, Schlegel B, Leidert M, Driller K, Turgay K, Schmieder P, Heinemann U, Oschkinat H. Roske Y, et al. Among authors: oschkinat h. Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2217070120. doi: 10.1073/pnas.2217070120. Epub 2023 Apr 17. Proc Natl Acad Sci U S A. 2023. PMID: 37068239 Free PMC article.
224 results