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Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity.
Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. Ellegood J, et al. Among authors: osborne lr. Mol Psychiatry. 2015 Feb;20(1):118-25. doi: 10.1038/mp.2014.98. Epub 2014 Sep 9. Mol Psychiatry. 2015. PMID: 25199916 Free PMC article.
3D visualization of the regional differences.
Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, Tam E, Osborne LR, Kouser M, Espinosa-Becerra F, Xuan Z, Powell CM, Raznahan A, Robins DM, Nakai N, Nakatani J, Takumi T, van Eede MC, Kerr TM, Muller C, Blakely RD, Veenstra-VanderWeele J, Henkelman RM, Lerch JP. Ellegood J, et al. Among authors: osborne lr. Mol Psychiatry. 2015 Feb;20(1):1. doi: 10.1038/mp.2014.168. Mol Psychiatry. 2015. PMID: 25648202 Free PMC article. No abstract available.
Exonic deletions in AUTS2 cause a syndromic form of intellectual disability and suggest a critical role for the C terminus.
Beunders G, Voorhoeve E, Golzio C, Pardo LM, Rosenfeld JA, Talkowski ME, Simonic I, Lionel AC, Vergult S, Pyatt RE, van de Kamp J, Nieuwint A, Weiss MM, Rizzu P, Verwer LE, van Spaendonk RM, Shen Y, Wu BL, Yu T, Yu Y, Chiang C, Gusella JF, Lindgren AM, Morton CC, van Binsbergen E, Bulk S, van Rossem E, Vanakker O, Armstrong R, Park SM, Greenhalgh L, Maye U, Neill NJ, Abbott KM, Sell S, Ladda R, Farber DM, Bader PI, Cushing T, Drautz JM, Konczal L, Nash P, de Los Reyes E, Carter MT, Hopkins E, Marshall CR, Osborne LR, Gripp KW, Thrush DL, Hashimoto S, Gastier-Foster JM, Astbury C, Ylstra B, Meijers-Heijboer H, Posthuma D, Menten B, Mortier G, Scherer SW, Eichler EE, Girirajan S, Katsanis N, Groffen AJ, Sistermans EA. Beunders G, et al. Among authors: osborne lr. Am J Hum Genet. 2013 Feb 7;92(2):210-20. doi: 10.1016/j.ajhg.2012.12.011. Epub 2013 Jan 17. Am J Hum Genet. 2013. PMID: 23332918 Free PMC article.
Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1-targeted mice.
Young EJ, Lipina T, Tam E, Mandel A, Clapcote SJ, Bechard AR, Chambers J, Mount HT, Fletcher PJ, Roder JC, Osborne LR. Young EJ, et al. Among authors: osborne lr. Genes Brain Behav. 2008 Mar;7(2):224-34. doi: 10.1111/j.1601-183X.2007.00343.x. Epub 2007 Aug 3. Genes Brain Behav. 2008. PMID: 17680805 Free PMC article.
7q11.23 deletion and duplication.
Osborne LR, Mervis CB. Osborne LR, et al. Curr Opin Genet Dev. 2021 Jun;68:41-48. doi: 10.1016/j.gde.2021.01.013. Epub 2021 Feb 17. Curr Opin Genet Dev. 2021. PMID: 33610060 Review.
85 results