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Synthesis, in vitro and in vivo pharmacological evaluation of serotoninergic ligands containing an isonicotinic nucleus.
Fiorino F, Ciano A, Magli E, Severino B, Corvino A, Perissutti E, Frecentese F, Di Vaio P, Izzo AA, Capasso R, Massarelli P, Nencini C, Rossi I, Kędzierska E, Orzelska-Gòrka J, Bielenica A, Santagada V, Caliendo G. Fiorino F, et al. Eur J Med Chem. 2016 Mar 3;110:133-50. doi: 10.1016/j.ejmech.2016.01.021. Epub 2016 Jan 18. Eur J Med Chem. 2016. PMID: 26820556
The adenosinergic system is involved in sensitization to morphine withdrawal signs in rats-neurochemical and molecular basis in dopaminergic system.
Listos J, Baranowska-Bosiacka I, Wąsik A, Talarek S, Tarnowski M, Listos P, Łupina M, Antkiewicz-Michaluk L, Gutowska I, Tkacz M, Pilutin A, Orzelska-Górka J, Chlubek D, Fidecka S. Listos J, et al. Psychopharmacology (Berl). 2016 Jun;233(12):2383-97. doi: 10.1007/s00213-016-4289-7. Epub 2016 Apr 18. Psychopharmacology (Berl). 2016. PMID: 27087433 Free PMC article.
In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048).
Aaltonen N, Kedzierska E, Orzelska-Górka J, Lehtonen M, Navia-Paldanius D, Jakupovic H, Savinainen JR, Nevalainen T, Laitinen JT, Parkkari T, Gynther M. Aaltonen N, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):62-72. doi: 10.1124/jpet.116.233114. Epub 2016 Jul 22. J Pharmacol Exp Ther. 2016. PMID: 27451409
New 5-HT1A, 5HT2A and 5HT2C receptor ligands containing a picolinic nucleus: Synthesis, in vitro and in vivo pharmacological evaluation.
Fiorino F, Magli E, Kędzierska E, Ciano A, Corvino A, Severino B, Perissutti E, Frecentese F, Di Vaio P, Saccone I, Izzo AA, Capasso R, Massarelli P, Rossi I, Orzelska-Gòrka J, Kotlińska JH, Santagada V, Caliendo G. Fiorino F, et al. Bioorg Med Chem. 2017 Oct 15;25(20):5820-5837. doi: 10.1016/j.bmc.2017.09.018. Epub 2017 Sep 18. Bioorg Med Chem. 2017. PMID: 28943244
23 results