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Ferritin Heavy Chain Binds Peroxiredoxin 6 and Inhibits Cell Proliferation and Migration.
Di Sanzo M, Cozzolino F, Battaglia AM, Aversa I, Monaco V, Sacco A, Biamonte F, Palmieri C, Procopio F, Santamaria G, Ortuso F, Pucci P, Monti M, Faniello MC. Di Sanzo M, et al. Among authors: ortuso f. Int J Mol Sci. 2022 Oct 26;23(21):12987. doi: 10.3390/ijms232112987. Int J Mol Sci. 2022. PMID: 36361777 Free PMC article.
8-Amide and 8-carbamate substitution patterns as modulators of 7-hydroxy-4-methylcoumarin's antidepressant profile: Synthesis, biological evaluation and docking studies.
Matos MJ, Novo P, Mayán L, Torres I, Uriarte E, Yáñez M, Fontenla JÁ, Ortuso F, Alcaro S, Procopio F, Rodríguez-Franco MI, Val C, Loza MI, Brea J, Borges F, Viña D. Matos MJ, et al. Among authors: ortuso f. Eur J Med Chem. 2023 Feb 15;248:115091. doi: 10.1016/j.ejmech.2023.115091. Epub 2023 Jan 7. Eur J Med Chem. 2023. PMID: 36638711 Free article.
Isolation and functional characterization of peptide agonists of PTPRJ, a tyrosine phosphatase receptor endowed with tumor suppressor activity.
Paduano F, Ortuso F, Campiglia P, Raso C, Iaccino E, Gaspari M, Gaudio E, Mangone G, Carotenuto A, Bilotta A, Narciso D, Palmieri C, Agosti V, Artese A, Gomez-Monterrey I, Sala M, Cuda G, Iuliano R, Perrotti N, Scala G, Viglietto G, Alcaro S, Croce CM, Novellino E, Fusco A, Trapasso F. Paduano F, et al. Among authors: ortuso f. ACS Chem Biol. 2012 Oct 19;7(10):1666-76. doi: 10.1021/cb300281t. Epub 2012 Jul 10. ACS Chem Biol. 2012. PMID: 22759068
Discovery of PTPRJ agonist peptides that effectively inhibit in vitro cancer cell proliferation and tube formation.
Ortuso F, Paduano F, Carotenuto A, Gomez-Monterrey I, Bilotta A, Gaudio E, Sala M, Artese A, Vernieri E, Dattilo V, Iuliano R, Brancaccio D, Bertamino A, Musella S, Alcaro S, Grieco P, Perrotti N, Croce CM, Novellino E, Fusco A, Campiglia P, Trapasso F. Ortuso F, et al. ACS Chem Biol. 2013 Jul 19;8(7):1497-506. doi: 10.1021/cb3007192. Epub 2013 May 13. ACS Chem Biol. 2013. PMID: 23627474
SI113, a specific inhibitor of the Sgk1 kinase activity that counteracts cancer cell proliferation.
D'Antona L, Amato R, Talarico C, Ortuso F, Menniti M, Dattilo V, Iuliano R, Gigliotti F, Artese A, Costa G, Schenone S, Musumeci F, Abbruzzese C, Botta L, Trapasso F, Alcaro S, Paggi MG, Perrotti N. D'Antona L, et al. Among authors: ortuso f. Cell Physiol Biochem. 2015;35(5):2006-18. doi: 10.1159/000374008. Epub 2015 Mar 27. Cell Physiol Biochem. 2015. PMID: 25871776 Free article.
Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy.
Talarico C, D'Antona L, Scumaci D, Barone A, Gigliotti F, Fiumara CV, Dattilo V, Gallo E, Visca P, Ortuso F, Abbruzzese C, Botta L, Schenone S, Cuda G, Alcaro S, Bianco C, Lavia P, Paggi MG, Perrotti N, Amato R. Talarico C, et al. Among authors: ortuso f. Oncotarget. 2015 Nov 10;6(35):37511-25. doi: 10.18632/oncotarget.5527. Oncotarget. 2015. PMID: 26462020 Free PMC article.
129 results