Orton RJ - Search Results

1

Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway.

Orton RJ, Sturm OE, Vyshemirsky V, Calder M, Gilbert DR, Kolch W. Orton RJ, et al. Biochem J. 2005 Dec 1;392(Pt 2):249-61. doi: 10.1042/BJ20050908. Biochem J. 2005. PMID: 16293107 Free PMC article. Review.

2

Omicron BA.2.86 cross-neutralising activity in community sera from the UK.

Willett BJ, Logan N, Scott S, Davis C, McSorley T, Asamaphan P, Hosie MJ, Olmo P, Grove J, Orton R, Ho A, Haughney J, Robertson DL, Thomson EC. Willett BJ, et al. Lancet. 2023 Dec 2;402(10417):2075-2076. doi: 10.1016/S0140-6736(23)02397-8. Epub 2023 Nov 9. Lancet. 2023. PMID: 37952549 No abstract available.

3

Computational methodologies for modelling, analysis and simulation of signalling networks.

Gilbert D, Fuss H, Gu X, Orton R, Robinson S, Vyshemirsky V, Kurth MJ, Downes CS, Dubitzky W. Gilbert D, et al. Brief Bioinform. 2006 Dec;7(4):339-53. doi: 10.1093/bib/bbl043. Epub 2006 Nov 20. Brief Bioinform. 2006. PMID: 17116646 Review.

4

A structured approach for the engineering of biochemical network models, illustrated for signalling pathways.

Breitling R, Gilbert D, Heiner M, Orton R. Breitling R, et al. Brief Bioinform. 2008 Sep;9(5):404-21. doi: 10.1093/bib/bbn026. Epub 2008 Jun 23. Brief Bioinform. 2008. PMID: 18573813 Free article. Review.

5

Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.

Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR. Orton RJ, et al. IET Syst Biol. 2008 Jul;2(4):173-83. doi: 10.1049/iet-syb:20070066. IET Syst Biol. 2008. PMID: 18681747 Free article.

6

Version control of pathway models using XML patches.

Saffrey P, Orton R. Saffrey P, et al. BMC Syst Biol. 2009 Mar 17;3:34. doi: 10.1186/1752-0509-3-34. BMC Syst Biol. 2009. PMID: 19292901 Free PMC article.

7

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway.

Orton RJ, Adriaens ME, Gormand A, Sturm OE, Kolch W, Gilbert DR. Orton RJ, et al. BMC Syst Biol. 2009 Oct 5;3:100. doi: 10.1186/1752-0509-3-100. BMC Syst Biol. 2009. PMID: 19804630 Free PMC article.

8

Cell fate decisions are specified by the dynamic ERK interactome.

von Kriegsheim A, Baiocchi D, Birtwistle M, Sumpton D, Bienvenut W, Morrice N, Yamada K, Lamond A, Kalna G, Orton R, Gilbert D, Kolch W. von Kriegsheim A, et al. Nat Cell Biol. 2009 Dec;11(12):1458-64. doi: 10.1038/ncb1994. Epub 2009 Nov 22. Nat Cell Biol. 2009. PMID: 19935650 Free PMC article.

9

Computational modelling of kinase signalling cascades.

Gilbert D, Heiner M, Breitling R, Orton R. Gilbert D, et al. Methods Mol Biol. 2010;661:369-84. doi: 10.1007/978-1-60761-795-2_22. Methods Mol Biol. 2010. PMID: 20811995

10

The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier.

Sturm OE, Orton R, Grindlay J, Birtwistle M, Vyshemirsky V, Gilbert D, Calder M, Pitt A, Kholodenko B, Kolch W. Sturm OE, et al. Sci Signal. 2010 Dec 21;3(153):ra90. doi: 10.1126/scisignal.2001212. Sci Signal. 2010. PMID: 21177493

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