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Page 1
Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility.
Douthwaite JA, Brown CA, Ferdinand JR, Sharma R, Elliott J, Taylor MA, Malintan NT, Duvoisin H, Hill T, Delpuech O, Orton AL, Pitt H, Kuenzi F, Fish S, Nicholls DJ, Cuthbert A, Richards I, Ratcliffe G, Upadhyay A, Marklew A, Hewitt C, Ross-Thriepland D, Brankin C, Chodorge M, Browne G, Mander PK, DeWildt RM, Weaver S, Smee PA, van Kempen J, Bartlett JG, Allen PM, Koppe EL, Ashby CA, Phipps JD, Mehta N, Brierley DJ, Tew DG, Leveridge MV, Baddeley SM, Goodfellow IG, Green C, Abell C, Neely A, Waddell I, Rees S, Maxwell PH, Pangalos MN, Howes R, Clark R. Douthwaite JA, et al. Among authors: orton al. Sci Rep. 2022 Feb 24;12(1):3114. doi: 10.1038/s41598-022-06873-6. Sci Rep. 2022. PMID: 35210470 Free PMC article.
Heat inactivation of clinical COVID-19 samples on an industrial scale for low risk and efficient high-throughput qRT-PCR diagnostic testing.
Delpuech O, Douthwaite JA, Hill T, Niranjan D, Malintan NT, Duvoisin H, Elliott J, Goodfellow I, Hosmillo M, Orton AL, Taylor MA, Brankin C, Pitt H, Ross-Thriepland D, Siek M, Cuthbert A, Richards I, Ferdinand JR, Barker C, Shaw R, Ariani C, Waddell I, Rees S, Green C, Clark R, Upadhyay A, Howes R. Delpuech O, et al. Among authors: orton al. Sci Rep. 2022 Feb 21;12(1):2883. doi: 10.1038/s41598-022-06888-z. Sci Rep. 2022. PMID: 35190592 Free PMC article.
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.
Aggarwal D, Warne B, Jahun AS, Hamilton WL, Fieldman T, du Plessis L, Hill V, Blane B, Watkins E, Wright E, Hall G, Ludden C, Myers R, Hosmillo M, Chaudhry Y, Pinckert ML, Georgana I, Izuagbe R, Leek D, Nsonwu O, Hughes GJ, Packer S, Page AJ, Metaxaki M, Fuller S, Weale G, Holgate J, Brown CA; Cambridge Covid-19 testing Centre; University of Cambridge Asymptomatic COVID-19 Screening Programme Consortium; COVID-19 Genomics UK (COG-UK) Consortium; Howes R, McFarlane D, Dougan G, Pybus OG, Angelis D, Maxwell PH, Peacock SJ, Weekes MP, Illingworth C, Harrison EM, Matheson NJ, Goodfellow IG. Aggarwal D, et al. Nat Commun. 2022 Feb 8;13(1):751. doi: 10.1038/s41467-021-27942-w. Nat Commun. 2022. PMID: 35136068 Free PMC article.
Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors.
Degorce SL, Aagaard A, Anjum R, Cumming IA, Diène CR, Fallan C, Johnson T, Leuchowius KJ, Orton AL, Pearson S, Robb GR, Rosen A, Scarfe GB, Scott JS, Smith JM, Steward OR, Terstiege I, Tucker MJ, Turner P, Wilkinson SD, Wrigley GL, Xue Y. Degorce SL, et al. Among authors: orton al. Bioorg Med Chem. 2020 Dec 1;28(23):115815. doi: 10.1016/j.bmc.2020.115815. Epub 2020 Oct 15. Bioorg Med Chem. 2020. PMID: 33091850
Expanding the Armory: Predicting and Tuning Covalent Warhead Reactivity.
Lonsdale R, Burgess J, Colclough N, Davies NL, Lenz EM, Orton AL, Ward RA. Lonsdale R, et al. Among authors: orton al. J Chem Inf Model. 2017 Dec 26;57(12):3124-3137. doi: 10.1021/acs.jcim.7b00553. Epub 2017 Nov 21. J Chem Inf Model. 2017. PMID: 29131621