Ortlund EA - Search Results

1

APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.

Blanchard JW, Akay LA, Davila-Velderrain J, von Maydell D, Mathys H, Davidson SM, Effenberger A, Chen CY, Maner-Smith K, Hajjar I, Ortlund EA, Bula M, Agbas E, Ng A, Jiang X, Kahn M, Blanco-Duque C, Lavoie N, Liu L, Reyes R, Lin YT, Ko T, R'Bibo L, Ralvenius WT, Bennett DA, Cam HP, Kellis M, Tsai LH. Blanchard JW, et al. Among authors: ortlund ea. Nature. 2022 Nov;611(7937):769-779. doi: 10.1038/s41586-022-05439-w. Epub 2022 Nov 16. Nature. 2022. PMID: 36385529 Free PMC article.

2

Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests.

Frank F, Keen MM, Rao A, Bassit L, Liu X, Bowers HB, Patel AB, Cato ML, Sullivan JA, Greenleaf M, Piantadosi A, Lam WA, Hudson WH, Ortlund EA. Frank F, et al. Among authors: ortlund ea. Cell. 2022 Sep 15;185(19):3603-3616.e13. doi: 10.1016/j.cell.2022.08.010. Epub 2022 Aug 29. Cell. 2022. PMID: 36084631 Free PMC article.

3

Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor.

Bridgham JT, Eick GN, Larroux C, Deshpande K, Harms MJ, Gauthier ME, Ortlund EA, Degnan BM, Thornton JW. Bridgham JT, et al. Among authors: ortlund ea. PLoS Biol. 2010 Oct 5;8(10):e1000497. doi: 10.1371/journal.pbio.1000497. PLoS Biol. 2010. PMID: 20957188 Free PMC article.

4

Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation.

Rey J, Hu H, Kyle F, Lai CF, Buluwela L, Coombes RC, Ortlund EA, Ali S, Snyder JP, Barrett AG. Rey J, et al. Among authors: ortlund ea. ChemMedChem. 2012 Nov;7(11):1909-14. doi: 10.1002/cmdc.201200307. Epub 2012 Sep 7. ChemMedChem. 2012. PMID: 22961990

5

First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-Activated γ Coactivator 1-α Complex with Endogenous and Synthetic Glucocorticoids.

Liu X, Wang Y, Ortlund EA. Liu X, et al. Among authors: ortlund ea. Mol Pharmacol. 2019 Oct;96(4):408-417. doi: 10.1124/mol.119.116806. Epub 2019 Aug 7. Mol Pharmacol. 2019. PMID: 31391291 Free PMC article.

6

Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex.

Mays SG, Okafor CD, Tuntland ML, Whitby RJ, Dharmarajan V, Stec J, Griffin PR, Ortlund EA. Mays SG, et al. Among authors: ortlund ea. Mol Pharmacol. 2017 Jul;92(1):1-11. doi: 10.1124/mol.117.108514. Epub 2017 Mar 31. Mol Pharmacol. 2017. PMID: 28363985 Free PMC article.

7

Crystal structures of human prostatic acid phosphatase in complex with a phosphate ion and alpha-benzylaminobenzylphosphonic acid update the mechanistic picture and offer new insights into inhibitor design.

Ortlund E, LaCount MW, Lebioda L. Ortlund E, et al. Biochemistry. 2003 Jan 21;42(2):383-9. doi: 10.1021/bi0265067. Biochemistry. 2003. PMID: 12525165

8

Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu.

Ortlund E, Lacount MW, Lewinski K, Lebioda L. Ortlund E, et al. Biochemistry. 2000 Feb 15;39(6):1199-204. doi: 10.1021/bi991797d. Biochemistry. 2000. PMID: 10684596

9

Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site.

Ortlund E, Parker CL, Schreck SF, Ginell S, Minor W, Sodetz JM, Lebioda L. Ortlund E, et al. Biochemistry. 2002 Jun 4;41(22):7030-7. doi: 10.1021/bi025696i. Biochemistry. 2002. PMID: 12033936

10

Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection.

Chen F, Gaucher EA, Leal NA, Hutter D, Havemann SA, Govindarajan S, Ortlund EA, Benner SA. Chen F, et al. Among authors: ortlund ea. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1948-53. doi: 10.1073/pnas.0908463107. Epub 2010 Jan 11. Proc Natl Acad Sci U S A. 2010. PMID: 20080675 Free PMC article.

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