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Colistin: Revival of an Old Polymyxin Antibiotic.
Dijkmans AC, Wilms EB, Kamerling IM, Birkhoff W, Ortiz-Zacarías NV, van Nieuwkoop C, Verbrugh HA, Touw DJ. Dijkmans AC, et al. Ther Drug Monit. 2015 Aug;37(4):419-27. doi: 10.1097/FTD.0000000000000172. Ther Drug Monit. 2015. PMID: 25549206 Review.
Sodium ion binding pocket mutations and adenosine A2A receptor function.
Massink A, Gutiérrez-de-Terán H, Lenselink EB, Ortiz Zacarías NV, Xia L, Heitman LH, Katritch V, Stevens RC, IJzerman AP. Massink A, et al. Mol Pharmacol. 2015 Feb;87(2):305-13. doi: 10.1124/mol.114.095737. Epub 2014 Dec 3. Mol Pharmacol. 2015. PMID: 25473121 Free PMC article.
Intracellular Receptor Modulation: Novel Approach to Target GPCRs.
Ortiz Zacarías NV, Lenselink EB, IJzerman AP, Handel TM, Heitman LH. Ortiz Zacarías NV, et al. Trends Pharmacol Sci. 2018 Jun;39(6):547-559. doi: 10.1016/j.tips.2018.03.002. Epub 2018 Apr 10. Trends Pharmacol Sci. 2018. PMID: 29653834 Free PMC article. Review.
Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2.
Ortiz Zacarías NV, van Veldhoven JPD, Portner L, van Spronsen E, Ullo S, Veenhuizen M, van der Velden WJC, Zweemer AJM, Kreekel RM, Oenema K, Lenselink EB, Heitman LH, IJzerman AP. Ortiz Zacarías NV, et al. J Med Chem. 2018 Oct 25;61(20):9146-9161. doi: 10.1021/acs.jmedchem.8b00605. Epub 2018 Oct 11. J Med Chem. 2018. PMID: 30256641 Free PMC article.
Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2.
Ortiz Zacarías NV, Chahal KK, Šimková T, van der Horst C, Zheng Y, Inoue A, Theunissen E, Mallee L, van der Es D, Louvel J, IJzerman AP, Handel TM, Kufareva I, Heitman LH. Ortiz Zacarías NV, et al. J Med Chem. 2021 Mar 11;64(5):2608-2621. doi: 10.1021/acs.jmedchem.0c01137. Epub 2021 Feb 18. J Med Chem. 2021. PMID: 33600174 Free PMC article.
Anticancer opportunities at every stage of chemokine function.
Ortiz Zacarías NV, Bemelmans MP, Handel TM, de Visser KE, Heitman LH. Ortiz Zacarías NV, et al. Trends Pharmacol Sci. 2021 Nov;42(11):912-928. doi: 10.1016/j.tips.2021.08.001. Epub 2021 Sep 11. Trends Pharmacol Sci. 2021. PMID: 34521537 Review.
Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold.
Thum S, Kokornaczyk AK, Seki T, De Maria M, Ortiz Zacarias NV, de Vries H, Weiss C, Koch M, Schepmann D, Kitamura M, Tschammer N, Heitman LH, Junker A, Wünsch B. Thum S, et al. Among authors: ortiz zacarias nv. Eur J Med Chem. 2017 Jul 28;135:401-413. doi: 10.1016/j.ejmech.2017.04.046. Epub 2017 Apr 22. Eur J Med Chem. 2017. PMID: 28463783
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