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IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus.
Karauzum H, Venkatasubramaniam A, Adhikari RP, Kort T, Holtsberg FW, Mukherjee I, Mednikov M, Ortines R, Nguyen NTQ, Doan TMN, Diep BA, Lee JC, Aman MJ. Karauzum H, et al. Among authors: ortines r. Front Immunol. 2021 Mar 10;12:624310. doi: 10.3389/fimmu.2021.624310. eCollection 2021. Front Immunol. 2021. PMID: 33777005 Free PMC article.
Dry and liquid formulations of IBT-V02, a novel multi-component toxoid vaccine, are effective against Staphylococcus aureus isolates from low-to-middle income countries.
Wang Y, Mukherjee I, Venkatasubramaniam A, Dikeman D, Orlando N, Zhang J, Ortines R, Mednikov M, Sherchand SP, Kanipakala T, Le T, Shukla S, Ketner M, Adhikari RP, Karauzum H, Aman MJ, Archer NK. Wang Y, et al. Among authors: ortines r. Front Immunol. 2024 Apr 3;15:1373367. doi: 10.3389/fimmu.2024.1373367. eCollection 2024. Front Immunol. 2024. PMID: 38633244 Free PMC article.
Pan-caspase inhibition as a potential host-directed immunotherapy against MRSA and other bacterial skin infections.
Alphonse MP, Rubens JH, Ortines RV, Orlando NA, Patel AM, Dikeman D, Wang Y, Vuong I, Joyce DP, Zhang J, Mumtaz M, Liu H, Liu Q, Youn C, Patrick GJ, Ravipati A, Miller RJ, Archer NK, Miller LS. Alphonse MP, et al. Among authors: ortines rv. Sci Transl Med. 2021 Jul 7;13(601):eabe9887. doi: 10.1126/scitranslmed.abe9887. Sci Transl Med. 2021. PMID: 34233954 Free PMC article.
Mouse model of hematogenous implant-related Staphylococcus aureus biofilm infection reveals therapeutic targets.
Wang Y, Cheng LI, Helfer DR, Ashbaugh AG, Miller RJ, Tzomides AJ, Thompson JM, Ortines RV, Tsai AS, Liu H, Dillen CA, Archer NK, Cohen TS, Tkaczyk C, Stover CK, Sellman BR, Miller LS. Wang Y, et al. Among authors: ortines rv. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5094-E5102. doi: 10.1073/pnas.1703427114. Epub 2017 Jun 12. Proc Natl Acad Sci U S A. 2017. PMID: 28607050 Free PMC article.
Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus aureus-Infected Wounds in Nondiabetic and Diabetic Mice.
Ortines RV, Liu H, Cheng LI, Cohen TS, Lawlor H, Gami A, Wang Y, Dillen CA, Archer NK, Miller RJ, Ashbaugh AG, Pinsker BL, Marchitto MC, Tkaczyk C, Stover CK, Sellman BR, Miller LS. Ortines RV, et al. Antimicrob Agents Chemother. 2018 Feb 23;62(3):e02288-17. doi: 10.1128/AAC.02288-17. Print 2018 Mar. Antimicrob Agents Chemother. 2018. PMID: 29311091 Free PMC article.
Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection.
Dillen CA, Pinsker BL, Marusina AI, Merleev AA, Farber ON, Liu H, Archer NK, Lee DB, Wang Y, Ortines RV, Lee SK, Marchitto MC, Cai SS, Ashbaugh AG, May LS, Holland SM, Freeman AF, Miller LG, Yeaman MR, Simon SI, Milner JD, Maverakis E, Miller LS. Dillen CA, et al. Among authors: ortines rv. J Clin Invest. 2018 Mar 1;128(3):1026-1042. doi: 10.1172/JCI96481. Epub 2018 Feb 5. J Clin Invest. 2018. PMID: 29400698 Free PMC article.
Clonal Vγ6+Vδ4+ T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection.
Marchitto MC, Dillen CA, Liu H, Miller RJ, Archer NK, Ortines RV, Alphonse MP, Marusina AI, Merleev AA, Wang Y, Pinsker BL, Byrd AS, Brown ID, Ravipati A, Zhang E, Cai SS, Limjunyawong N, Dong X, Yeaman MR, Simon SI, Shen W, Durum SK, O'Brien RL, Maverakis E, Miller LS. Marchitto MC, et al. Among authors: ortines rv. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10917-10926. doi: 10.1073/pnas.1818256116. Epub 2019 May 14. Proc Natl Acad Sci U S A. 2019. PMID: 31088972 Free PMC article.
30 results