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In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts.
Imhof D, Anghel N, Winzer P, Balmer V, Ramseier J, Hänggeli K, Choi R, Hulverson MA, Whitman GR, Arnold SLM, Ojo KK, Van Voorhis WC, Doggett JS, Ortega-Mora LM, Hemphill A. Imhof D, et al. Int J Parasitol Drugs Drug Resist. 2021 Aug;16:90-101. doi: 10.1016/j.ijpddr.2021.05.001. Epub 2021 May 18. Int J Parasitol Drugs Drug Resist. 2021. PMID: 34030110 Free PMC article.
Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo.
Anghel N, Imhof D, Winzer P, Balmer V, Ramseier J, Haenggeli K, Choi R, Hulverson MA, Whitman GR, Arnold SLM, Ojo KK, Van Voorhis WC, Doggett JS, Ortega-Mora LM, Hemphill A. Anghel N, et al. Int J Parasitol Drugs Drug Resist. 2021 Dec;17:92-106. doi: 10.1016/j.ijpddr.2021.08.007. Epub 2021 Aug 28. Int J Parasitol Drugs Drug Resist. 2021. PMID: 34482255 Free PMC article.
A live vaccine against Neospora caninum abortions in cattle.
Reichel MP, Moore DP, Hemphill A, Ortega-Mora LM, Dubey JP, Ellis JT. Reichel MP, et al. Vaccine. 2015 Mar 10;33(11):1299-301. doi: 10.1016/j.vaccine.2015.01.064. Epub 2015 Feb 7. Vaccine. 2015. PMID: 25659274 No abstract available.
The tandemly repeated NTPase (NTPDase) from Neospora caninum is a canonical dense granule protein whose RNA expression, protein secretion and phosphorylation coincides with the tachyzoite egress.
Pastor-Fernández I, Regidor-Cerrillo J, Álvarez-García G, Marugán-Hernández V, García-Lunar P, Hemphill A, Ortega-Mora LM. Pastor-Fernández I, et al. Parasit Vectors. 2016 Jun 21;9(1):352. doi: 10.1186/s13071-016-1620-4. Parasit Vectors. 2016. PMID: 27329357 Free PMC article.
In vitro efficacy of bumped kinase inhibitors against Besnoitia besnoiti tachyzoites.
Jiménez-Meléndez A, Ojo KK, Wallace AM, Smith TR, Hemphill A, Balmer V, Regidor-Cerrillo J, Ortega-Mora LM, Hehl AB, Fan E, Maly DJ, Van Voorhis WC, Álvarez-García G. Jiménez-Meléndez A, et al. Int J Parasitol. 2017 Oct;47(12):811-821. doi: 10.1016/j.ijpara.2017.08.005. Epub 2017 Sep 9. Int J Parasitol. 2017. PMID: 28899692
284 results