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An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer.
Myers SH, Poppi L, Rinaldi F, Veronesi M, Ciamarone A, Previtali V, Bagnolini G, Schipani F, Ortega Martínez JA, Girotto S, Di Stefano G, Farabegoli F, Walsh N, De Franco F, Roberti M, Cavalli A. Myers SH, et al. Among authors: ortega martinez ja. Eur J Med Chem. 2024 Feb 5;265:116114. doi: 10.1016/j.ejmech.2023.116114. Epub 2023 Dec 31. Eur J Med Chem. 2024. PMID: 38194775 Free article.
Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5.
Brusa I, Sondo E, Pesce E, Tomati V, Gioia D, Falchi F, Balboni B, Ortega Martínez JA, Veronesi M, Romeo E, Margaroli N, Recanatini M, Girotto S, Pedemonte N, Roberti M, Cavalli A. Brusa I, et al. Among authors: ortega martinez ja. J Med Chem. 2023 Jul 27;66(14):9797-9822. doi: 10.1021/acs.jmedchem.3c00608. Epub 2023 Jul 13. J Med Chem. 2023. PMID: 37440686 Free PMC article.