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Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.
Pogribny IP, Dreval K, Kindrat I, Melnyk S, Jimenez L, de Conti A, Tryndyak V, Pogribna M, Ortega JF, James SJ, Rusyn I, Beland FA. Pogribny IP, et al. Among authors: ortega jf. FASEB J. 2018 Mar;32(3):1591-1601. doi: 10.1096/fj.201700866R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29127188 Free PMC article.
Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein.
Ortega JF, de Conti A, Tryndyak V, Furtado KS, Heidor R, Horst MA, Fernandes LH, Tavares PE, Pogribna M, Shpyleva S, Beland FA, Pogribny IP, Moreno FS. Ortega JF, et al. Oncotarget. 2016 Apr 26;7(17):24339-47. doi: 10.18632/oncotarget.8248. Oncotarget. 2016. PMID: 27013579 Free PMC article.
Anticarcinogenic actions of tributyrin, a butyric acid prodrug.
Heidor R, Ortega JF, de Conti A, Ong TP, Moreno FS. Heidor R, et al. Among authors: ortega jf. Curr Drug Targets. 2012 Dec;13(14):1720-9. doi: 10.2174/138945012804545443. Curr Drug Targets. 2012. PMID: 23140283 Review.
The chemopreventive activity of the histone deacetylase inhibitor tributyrin in colon carcinogenesis involves the induction of apoptosis and reduction of DNA damage.
Heidor R, Furtado KS, Ortega JF, de Oliveira TF, Tavares PE, Vieira A, Miranda ML, Purgatto E, Moreno FS. Heidor R, et al. Among authors: ortega jf. Toxicol Appl Pharmacol. 2014 Apr 15;276(2):129-35. doi: 10.1016/j.taap.2014.02.004. Epub 2014 Feb 25. Toxicol Appl Pharmacol. 2014. PMID: 24576724
A bout of aerobic exercise in the heat increases carbohydrate use but does not enhance the disposal of an oral glucose load, in healthy active individuals.
Mora-Rodriguez R, Moreno-Cabañas A, Alvarez-Jimenez L, Mora-Gonzalez D, Ortega JF, Morales-Palomo F. Mora-Rodriguez R, et al. Among authors: ortega jf. Am J Physiol Endocrinol Metab. 2024 May 1;326(5):E648-E662. doi: 10.1152/ajpendo.00312.2023. Epub 2024 Apr 3. Am J Physiol Endocrinol Metab. 2024. PMID: 38568152 Clinical Trial.
93 results