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Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.
Lluch A, Latorre J, Serena-Maione A, Espadas I, Caballano-Infantes E, Moreno-Navarrete JM, Oliveras-Cañellas N, Ricart W, Malagón MM, Martin-Montalvo A, Birchmeier W, Szymanski W, Graumann J, Gómez-Serrano M, Sommariva E, Fernández-Real JM, Ortega FJ. Lluch A, et al. Among authors: ortega fj. Nat Commun. 2023 Aug 22;14(1):5106. doi: 10.1038/s41467-023-40596-0. Nat Commun. 2023. PMID: 37607954 Free PMC article.
Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis.
Amin A, Badenes M, Tüshaus J, de Carvalho É, Burbridge E, Faísca P, Trávníčková K, Barros A, Carobbio S, Domingos PM, Vidal-Puig A, Moita LF, Maguire S, Stříšovský K, Ortega FJ, Fernández-Real JM, Lichtenthaler SF, Adrain C. Amin A, et al. Among authors: ortega fj. Mol Metab. 2023 Jul;73:101731. doi: 10.1016/j.molmet.2023.101731. Epub 2023 Apr 28. Mol Metab. 2023. PMID: 37121509 Free PMC article.
A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells.
González-Moro I, Rojas-Márquez H, Sebastian-delaCruz M, Mentxaka-Salgado J, Olazagoitia-Garmendia A, Mendoza LM, Lluch A, Fantuzzi F, Lambert C, Ares Blanco J, Marselli L, Marchetti P, Cnop M, Delgado E, Fernández-Real JM, Ortega FJ, Castellanos-Rubio A, Santin I. González-Moro I, et al. Among authors: ortega fj. Front Endocrinol (Lausanne). 2023 Feb 7;14:1101934. doi: 10.3389/fendo.2023.1101934. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 36824360 Free PMC article.
A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis.
Lluch A, Veiga SR, Latorre J, Moreno-Navarrete JM, Bonifaci N, Dien Nguyen V, Zhou Y, Höring M, Liebisch G, Olkkonen VM, Llobet-Navas D, Thomas G, Rodríguez-Barrueco R, Fernández-Real JM, Kozma SC, Ortega FJ. Lluch A, et al. Among authors: ortega fj. JCI Insight. 2022 Jul 22;7(14):e150461. doi: 10.1172/jci.insight.150461. JCI Insight. 2022. PMID: 35737463 Free PMC article.
Diabetes Does Not Increase the Risk of Hospitalization Due to COVID-19 in Patients Aged 50 Years or Older in Primary Care-APHOSDIAB-COVID-19 Multicenter Study.
Orozco-Beltrán D, Merino-Torres JF, Pérez A, Cebrián-Cuenca AM, Párraga-Martínez I, Ávila-Lachica L, Rojo-Martínez G, Pomares-Gómez FJ, Álvarez-Guisasola F, Sánchez-Molla M, Gutiérrez F, Ortega FJ, Mata-Cases M, Carretero-Anibarro E, Vilaseca JM, Quesada JA. Orozco-Beltrán D, et al. Among authors: ortega fj. J Clin Med. 2022 Apr 8;11(8):2092. doi: 10.3390/jcm11082092. J Clin Med. 2022. PMID: 35456185 Free PMC article.
121 results