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Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.
Travelli C, Aprile S, Rahimian R, Grolla AA, Rogati F, Bertolotti M, Malagnino F, di Paola R, Impellizzeri D, Fusco R, Mercalli V, Massarotti A, Stortini G, Terrazzino S, Del Grosso E, Fakhfouri G, Troiani MP, Alisi MA, Grosa G, Sorba G, Canonico PL, Orsomando G, Cuzzocrea S, Genazzani AA, Galli U, Tron GC. Travelli C, et al. Among authors: orsomando g. J Med Chem. 2017 Mar 9;60(5):1768-1792. doi: 10.1021/acs.jmedchem.6b01392. Epub 2017 Feb 22. J Med Chem. 2017. PMID: 28165742
A nicotinamide phosphoribosyltransferase-GAPDH interaction sustains the stress-induced NMN/NAD+ salvage pathway in the nucleus.
Grolla AA, Miggiano R, Di Marino D, Bianchi M, Gori A, Orsomando G, Gaudino F, Galli U, Del Grosso E, Mazzola F, Angeletti C, Guarneri M, Torretta S, Calabrò M, Boumya S, Fan X, Colombo G, Travelli C, Rocchio F, Aronica E, Wohlschlegel JA, Deaglio S, Rizzi M, Genazzani AA, Garavaglia S. Grolla AA, et al. Among authors: orsomando g. J Biol Chem. 2020 Mar 13;295(11):3635-3651. doi: 10.1074/jbc.RA119.010571. Epub 2020 Jan 27. J Biol Chem. 2020. PMID: 31988240 Free PMC article.
Metabolic profiling of alternative NAD biosynthetic routes in mouse tissues.
Mori V, Amici A, Mazzola F, Di Stefano M, Conforti L, Magni G, Ruggieri S, Raffaelli N, Orsomando G. Mori V, et al. Among authors: orsomando g. PLoS One. 2014 Nov 25;9(11):e113939. doi: 10.1371/journal.pone.0113939. eCollection 2014. PLoS One. 2014. PMID: 25423279 Free PMC article.
Crystal structure of human nicotinic acid phosphoribosyltransferase.
Marletta AS, Massarotti A, Orsomando G, Magni G, Rizzi M, Garavaglia S. Marletta AS, et al. Among authors: orsomando g. FEBS Open Bio. 2015 May 7;5:419-28. doi: 10.1016/j.fob.2015.05.002. eCollection 2015. FEBS Open Bio. 2015. PMID: 26042198 Free PMC article.
46 results