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Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection.
Ahuja SK, Manoharan MS, Lee GC, McKinnon LR, Meunier JA, Steri M, Harper N, Fiorillo E, Smith AM, Restrepo MI, Branum AP, Bottomley MJ, Orrù V, Jimenez F, Carrillo A, Pandranki L, Winter CA, Winter LA, Gaitan AA, Moreira AG, Walter EA, Silvestri G, King CL, Zheng YT, Zheng HY, Kimani J, Blake Ball T, Plummer FA, Fowke KR, Harden PN, Wood KJ, Ferris MT, Lund JM, Heise MT, Garrett N, Canady KR, Abdool Karim SS, Little SJ, Gianella S, Smith DM, Letendre S, Richman DD, Cucca F, Trinh H, Sanchez-Reilly S, Hecht JM, Cadena Zuluaga JA, Anzueto A, Pugh JA; South Texas Veterans Health Care System COVID-19 team; Agan BK, Root-Bernstein R, Clark RA, Okulicz JF, He W. Ahuja SK, et al. Among authors: orru v. Nat Commun. 2023 Jun 13;14(1):3286. doi: 10.1038/s41467-023-38238-6. Nat Commun. 2023. PMID: 37311745 Free PMC article.
Genetic variants in mRNA untranslated regions.
Steri M, Idda ML, Whalen MB, Orrù V. Steri M, et al. Among authors: orru v. Wiley Interdiscip Rev RNA. 2018 Jul;9(4):e1474. doi: 10.1002/wrna.1474. Epub 2018 Mar 26. Wiley Interdiscip Rev RNA. 2018. PMID: 29582564 Free PMC article. Review.
CD8+HLADR+ Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function.
Lukas Yani S, Keller M, Melzer FL, Weinberger B, Pangrazzi L, Sopper S, Trieb K, Lobina M, Orrù V, Fiorillo E, Cucca F, Grubeck-Loebenstein B. Lukas Yani S, et al. Among authors: orru v. Front Immunol. 2018 Jun 4;9:1201. doi: 10.3389/fimmu.2018.01201. eCollection 2018. Front Immunol. 2018. PMID: 29915580 Free PMC article.
Cooperative translational control of polymorphic BAFF by NF90 and miR-15a.
Idda ML, Lodde V, McClusky WG, Martindale JL, Yang X, Munk R, Steri M, Orrù V, Mulas A, Cucca F, Abdelmohsen K, Gorospe M. Idda ML, et al. Among authors: orru v. Nucleic Acids Res. 2018 Dec 14;46(22):12040-12051. doi: 10.1093/nar/gky866. Nucleic Acids Res. 2018. PMID: 30272251 Free PMC article.
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells and PD-1 Expression.
Ferreira RC, Castro Dopico X, Oliveira JJ, Rainbow DB, Yang JH, Trzupek D, Todd SA, McNeill M, Steri M, Orrù V, Fiorillo E, Crouch DJM, Pekalski ML, Cucca F, Tree TI, Vyse TJ, Wicker LS, Todd JA. Ferreira RC, et al. Among authors: orru v. Front Immunol. 2019 Nov 8;10:2606. doi: 10.3389/fimmu.2019.02606. eCollection 2019. Front Immunol. 2019. PMID: 31781109 Free PMC article.
Complex genetic signatures in immune cells underlie autoimmunity and inform therapy.
Orrù V, Steri M, Sidore C, Marongiu M, Serra V, Olla S, Sole G, Lai S, Dei M, Mulas A, Virdis F, Piras MG, Lobina M, Marongiu M, Pitzalis M, Deidda F, Loizedda A, Onano S, Zoledziewska M, Sawcer S, Devoto M, Gorospe M, Abecasis GR, Floris M, Pala M, Schlessinger D, Fiorillo E, Cucca F. Orrù V, et al. Nat Genet. 2020 Oct;52(10):1036-1045. doi: 10.1038/s41588-020-0684-4. Epub 2020 Sep 14. Nat Genet. 2020. PMID: 32929287 Free PMC article.
Author Correction: Complex genetic signatures in immune cells underlie autoimmunity and inform therapy.
Orrù V, Steri M, Sidore C, Marongiu M, Serra V, Olla S, Sole G, Lai S, Dei M, Mulas A, Virdis F, Piras MG, Lobina M, Marongiu M, Pitzalis M, Deidda F, Loizedda A, Onano S, Zoledziewska M, Sawcer S, Devoto M, Gorospe M, Abecasis GR, Floris M, Pala M, Schlessinger D, Fiorillo E, Cucca F. Orrù V, et al. Nat Genet. 2020 Nov;52(11):1266. doi: 10.1038/s41588-020-00718-6. Nat Genet. 2020. PMID: 32948852
52 results