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Page 1
Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the disease.
Garrido-Maraver J, Cordero MD, Moñino ID, Pereira-Arenas S, Lechuga-Vieco AV, Cotán D, De la Mata M, Oropesa-Ávila M, De Miguel M, Bautista Lorite J, Rivas Infante E, Alvarez-Dolado M, Navas P, Jackson S, Francisci S, Sánchez-Alcázar JA. Garrido-Maraver J, et al. Br J Pharmacol. 2012 Nov;167(6):1311-28. doi: 10.1111/j.1476-5381.2012.02086.x. Br J Pharmacol. 2012. PMID: 22747838 Free PMC article.
Coenzyme Q10 and alpha-tocopherol protect against amitriptyline toxicity.
Cordero MD, Moreno-Fernández AM, Gomez-Skarmeta JL, de Miguel M, Garrido-Maraver J, Oropesa-Avila M, Rodríguez-Hernández A, Navas P, Sánchez-Alcázar JA. Cordero MD, et al. Toxicol Appl Pharmacol. 2009 Mar 15;235(3):329-37. doi: 10.1016/j.taap.2008.12.026. Toxicol Appl Pharmacol. 2009. PMID: 19263520
Recovery of MERRF fibroblasts and cybrids pathophysiology by coenzyme Q10.
De la Mata M, Garrido-Maraver J, Cotán D, Cordero MD, Oropesa-Ávila M, Izquierdo LG, De Miguel M, Lorite JB, Infante ER, Ybot P, Jackson S, Sánchez-Alcázar JA. De la Mata M, et al. Neurotherapeutics. 2012 Apr;9(2):446-63. doi: 10.1007/s13311-012-0103-3. Neurotherapeutics. 2012. PMID: 22354625 Free PMC article.
Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease.
de la Mata M, Cotán D, Oropesa-Ávila M, Garrido-Maraver J, Cordero MD, Villanueva Paz M, Delgado Pavón A, Alcocer-Gómez E, de Lavera I, Ybot-González P, Paula Zaderenko A, Ortiz Mellet C, García Fernández JM, Sánchez-Alcázar JA. de la Mata M, et al. Sci Rep. 2015 Jun 5;5:10903. doi: 10.1038/srep10903. Sci Rep. 2015. PMID: 26045184 Free PMC article.
Stabilization of apoptotic cells: generation of zombie cells.
Oropesa-Ávila M, Andrade-Talavera Y, Garrido-Maraver J, Cordero MD, de la Mata M, Cotán D, Paz MV, Pavón AD, Alcocer-Gómez E, de Lavera I, Lema R, Zaderenko AP, Rodríguez-Moreno A, Sánchez-Alcázar JA. Oropesa-Ávila M, et al. Cell Death Dis. 2014 Aug 14;5(8):e1369. doi: 10.1038/cddis.2014.332. Cell Death Dis. 2014. PMID: 25118929 Free PMC article.
Clinical applications of coenzyme Q10.
Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Vega AF, de la Mata M, Pavon AD, Alcocer-Gomez E, Calero CP, Paz MV, Alanis M, de Lavera I, Cotan D, Sanchez-Alcazar JA. Garrido-Maraver J, et al. Front Biosci (Landmark Ed). 2014 Jan 1;19(4):619-33. doi: 10.2741/4231. Front Biosci (Landmark Ed). 2014. PMID: 24389208 Free article. Review.
Coenzyme q10 therapy.
Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, Fernández Vega A, de la Mata M, Delgado Pavón A, de Miguel M, Pérez Calero C, Villanueva Paz M, Cotán D, Sánchez-Alcázar JA. Garrido-Maraver J, et al. Mol Syndromol. 2014 Jul;5(3-4):187-97. doi: 10.1159/000360101. Mol Syndromol. 2014. PMID: 25126052 Free PMC article.
Critical role of AMP-activated protein kinase in the balance between mitophagy and mitochondrial biogenesis in MELAS disease.
Garrido-Maraver J, Paz MV, Cordero MD, Bautista-Lorite J, Oropesa-Ávila M, de la Mata M, Pavón AD, de Lavera I, Alcocer-Gómez E, Galán F, Ybot González P, Cotán D, Jackson S, Sánchez-Alcázar JA. Garrido-Maraver J, et al. Biochim Biophys Acta. 2015 Nov;1852(11):2535-53. doi: 10.1016/j.bbadis.2015.08.027. Epub 2015 Sep 2. Biochim Biophys Acta. 2015. PMID: 26341273 Free article. No abstract available.
Targeting autophagy and mitophagy for mitochondrial diseases treatment.
Villanueva Paz M, Cotán D, Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, de La Mata M, Delgado Pavón A, de Lavera I, Alcocer-Gómez E, Sánchez-Alcázar JA. Villanueva Paz M, et al. Expert Opin Ther Targets. 2016;20(4):487-500. doi: 10.1517/14728222.2016.1101068. Epub 2015 Nov 2. Expert Opin Ther Targets. 2016. PMID: 26523761 Review.
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