Orman M - Search Results

1

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.

Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A, Stockwell BR. Skouta R, et al. Among authors: orman m. J Am Chem Soc. 2014 Mar 26;136(12):4551-6. doi: 10.1021/ja411006a. Epub 2014 Mar 14. J Am Chem Soc. 2014. PMID: 24592866 Free PMC article.

2

Structure-Guided Identification of a Small Molecule That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria.

Orman M, Bodea S, Funk MA, Campo AM, Bollenbach M, Drennan CL, Balskus EP. Orman M, et al. J Am Chem Soc. 2019 Jan 9;141(1):33-37. doi: 10.1021/jacs.8b04883. Epub 2018 Dec 17. J Am Chem Soc. 2019. PMID: 30557011 Free PMC article.

3

O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix.

Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S. Levine ZG, et al. Among authors: orman m. J Am Chem Soc. 2018 Mar 14;140(10):3510-3513. doi: 10.1021/jacs.7b13546. Epub 2018 Mar 5. J Am Chem Soc. 2018. PMID: 29485866 Free PMC article.

4

A small molecule that inhibits OGT activity in cells.

Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S. Ortiz-Meoz RF, et al. Among authors: orman m. ACS Chem Biol. 2015 Jun 19;10(6):1392-7. doi: 10.1021/acschembio.5b00004. Epub 2015 Mar 18. ACS Chem Biol. 2015. PMID: 25751766 Free PMC article.

5

Discovery of a Cyclic Choline Analog That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria.

Bollenbach M, Ortega M, Orman M, Drennan CL, Balskus EP. Bollenbach M, et al. Among authors: orman m. ACS Med Chem Lett. 2020 Mar 25;11(10):1980-1985. doi: 10.1021/acsmedchemlett.0c00005. eCollection 2020 Oct 8. ACS Med Chem Lett. 2020. PMID: 33062182 Free PMC article.

6

Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu⁺ supplants entropically favoured Zn²⁺ to form Cu₄ ⁺ clusters under physiological conditions.

Mehlenbacher MR, Elsiesy R, Lakha R, Villones RLE, Orman M, Vizcarra CL, Meloni G, Wilcox DE, Austin RN. Mehlenbacher MR, et al. Among authors: orman m. Chem Sci. 2022 Apr 4;13(18):5289-5304. doi: 10.1039/d2sc00676f. eCollection 2022 May 11. Chem Sci. 2022. PMID: 35655557 Free PMC article.

7

An alkane monooxygenase (AlkB) family in which all electron transfer partners are covalently bound to the oxygen-activating hydroxylase.

Williams SC, Luongo D, Orman M, Vizcarra CL, Austin RN. Williams SC, et al. Among authors: orman m. J Inorg Biochem. 2022 Mar;228:111707. doi: 10.1016/j.jinorgbio.2021.111707. Epub 2021 Dec 31. J Inorg Biochem. 2022. PMID: 34990970 Free PMC article.

8

Alterations to the broad-spectrum formin inhibitor SMIFH2 modulate potency but not specificity.

Orman M, Landis M, Oza A, Nambiar D, Gjeci J, Song K, Huang V, Klestzick A, Hachicho C, Liu SQ, Kamm JM, Bartolini F, Vadakkan JJ, Rojas CM, Vizcarra CL. Orman M, et al. Sci Rep. 2022 Aug 8;12(1):13520. doi: 10.1038/s41598-022-17685-z. Sci Rep. 2022. PMID: 35941181 Free PMC article.

9

Experimental and computational mechanistic investigation of chlorocarbene additions to bridgehead carbene-anti-Bredt systems: noradamantylcarbene-adamantene and adamantylcarbene-homoadamantene.

Hare SR, Orman M, Dewan F, Dalchand E, Buzard C, Ahmed S, Tolentino JC, Sethi U, Terlizzi K, Houferak C, Stein AM, Stedronsky A, Thamattoor DM, Tantillo DJ, Merrer DC. Hare SR, et al. Among authors: orman m. J Org Chem. 2015 May 15;80(10):5049-65. doi: 10.1021/acs.joc.5b00456. Epub 2015 May 6. J Org Chem. 2015. PMID: 25902301

10

NPEPPS Is a Druggable Driver of Platinum Resistance.

Jones RT, Scholtes M, Goodspeed A, Akbarzadeh M, Mohapatra S, Feldman LE, Vekony H, Jean A, Tilton CB, Orman MV, Romal S, Deiter C, Kan TW, Xander N, Araki SP, Joshi M, Javaid M, Clambey ET, Layer R, Laajala TD, Parker SJ, Mahmoudi T, Zuiverloon TCM, Theodorescu D, Costello JC. Jones RT, et al. Among authors: orman mv. Cancer Res. 2024 May 15;84(10):1699-1718. doi: 10.1158/0008-5472.CAN-23-1976. Cancer Res. 2024. PMID: 38535994

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