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Novel nonnucleoside inhibitor of hepatitis C virus RNA-dependent RNA polymerase.
Howe AY, Bloom J, Baldick CJ, Benetatos CA, Cheng H, Christensen JS, Chunduru SK, Coburn GA, Feld B, Gopalsamy A, Gorczyca WP, Herrmann S, Johann S, Jiang X, Kimberland ML, Krisnamurthy G, Olson M, Orlowski M, Swanberg S, Thompson I, Thorn M, Del Vecchio A, Young DC, van Zeijl M, Ellingboe JW, Upeslacis J, Collett M, Mansour TS, O'Connell JF. Howe AY, et al. Among authors: orlowski m. Antimicrob Agents Chemother. 2004 Dec;48(12):4813-21. doi: 10.1128/AAC.48.12.4813-4821.2004. Antimicrob Agents Chemother. 2004. PMID: 15561861 Free PMC article.
Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors.
Gopalsamy A, Lim K, Ciszewski G, Park K, Ellingboe JW, Bloom J, Insaf S, Upeslacis J, Mansour TS, Krishnamurthy G, Damarla M, Pyatski Y, Ho D, Howe AY, Orlowski M, Feld B, O'Connell J. Gopalsamy A, et al. Among authors: orlowski m. J Med Chem. 2004 Dec 16;47(26):6603-8. doi: 10.1021/jm0401255. J Med Chem. 2004. PMID: 15588095
Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.
Gopalsamy A, Aplasca A, Ciszewski G, Park K, Ellingboe JW, Orlowski M, Feld B, Howe AY. Gopalsamy A, et al. Among authors: orlowski m. Bioorg Med Chem Lett. 2006 Jan 15;16(2):457-60. doi: 10.1016/j.bmcl.2005.08.114. Epub 2005 Nov 7. Bioorg Med Chem Lett. 2006. PMID: 16274990
Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.
Gopalsamy A, Shi M, Ciszewski G, Park K, Ellingboe JW, Orlowski M, Feld B, Howe AY. Gopalsamy A, et al. Among authors: orlowski m. Bioorg Med Chem Lett. 2006 May 1;16(9):2532-4. doi: 10.1016/j.bmcl.2006.01.105. Epub 2006 Feb 15. Bioorg Med Chem Lett. 2006. PMID: 16480869
Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.
Gopalsamy A, Chopra R, Lim K, Ciszewski G, Shi M, Curran KJ, Sukits SF, Svenson K, Bard J, Ellingboe JW, Agarwal A, Krishnamurthy G, Howe AY, Orlowski M, Feld B, O'Connell J, Mansour TS. Gopalsamy A, et al. Among authors: orlowski m. J Med Chem. 2006 Jun 1;49(11):3052-5. doi: 10.1021/jm060168g. J Med Chem. 2006. PMID: 16722622
Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.
Nittoli T, Curran K, Insaf S, DiGrandi M, Orlowski M, Chopra R, Agarwal A, Howe AY, Prashad A, Floyd MB, Johnson B, Sutherland A, Wheless K, Feld B, O'Connell J, Mansour TS, Bloom J. Nittoli T, et al. Among authors: orlowski m. J Med Chem. 2007 May 3;50(9):2108-16. doi: 10.1021/jm061428x. Epub 2007 Apr 3. J Med Chem. 2007. PMID: 17402724
Diagnostic PCR analysis of the occurrence of methicillin and tetracycline resistance genes among Staphylococcus aureus isolates from phase 3 clinical trials of tigecycline for complicated skin and skin structure infections.
Jones CH, Tuckman M, Howe AY, Orlowski M, Mullen S, Chan K, Bradford PA. Jones CH, et al. Among authors: orlowski m. Antimicrob Agents Chemother. 2006 Feb;50(2):505-10. doi: 10.1128/AAC.50.2.505-510.2006. Antimicrob Agents Chemother. 2006. PMID: 16436703 Free PMC article.
298 results