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Murine regulatory T cells induce death of effector T, B, and NK lymphocytes through a contact-independent mechanism involving telomerase suppression and telomere-associated senescence.
Zhdanov DD, Gladilina YA, Pokrovsky VS, Grishin DV, Grachev VA, Orlova VS, Pokrovskaya MV, Alexandrova SS, Sokolov NN. Zhdanov DD, et al. Among authors: orlova vs. Cell Immunol. 2018 Sep;331:146-160. doi: 10.1016/j.cellimm.2018.06.008. Epub 2018 Jun 19. Cell Immunol. 2018. PMID: 29935763
Inhibition of telomerase activity by splice-switching oligonucleotides targeting the mRNA of the telomerase catalytic subunit affects proliferation of human CD4+ T lymphocytes.
Zhdanov DD, Plyasova AA, Gladilina YA, Pokrovsky VS, Grishin DV, Grachev VA, Orlova VS, Pokrovskaya MV, Alexandrova SS, Lobaeva TA, Sokolov NN. Zhdanov DD, et al. Among authors: orlova vs. Biochem Biophys Res Commun. 2019 Feb 12;509(3):790-796. doi: 10.1016/j.bbrc.2018.12.186. Epub 2019 Jan 4. Biochem Biophys Res Commun. 2019. PMID: 30612734
[Induction of apoptotic endonuclease EndoG with DNA-damaging agents initiates alternative splicing of telomerase catalytic subunit hTERT and inhibition of telomerase activity hTERT in human CD4+ and CD8+ T-lymphocytes].
Zhdanov DD, Vasina DA, Orlova VS, Orlova EV, Grishin DV, Gladilina YA, Pokrovskaya MV, Aleksandrova SS, Sokolov NN. Zhdanov DD, et al. Among authors: orlova vs. Biomed Khim. 2017 Jul;63(4):296-305. doi: 10.18097/PBMC20176304296. Biomed Khim. 2017. PMID: 28862599 Russian.
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