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Page 1
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia.
Fraietta JA, Lacey SF, Orlando EJ, Pruteanu-Malinici I, Gohil M, Lundh S, Boesteanu AC, Wang Y, O'Connor RS, Hwang WT, Pequignot E, Ambrose DE, Zhang C, Wilcox N, Bedoya F, Dorfmeier C, Chen F, Tian L, Parakandi H, Gupta M, Young RM, Johnson FB, Kulikovskaya I, Liu L, Xu J, Kassim SH, Davis MM, Levine BL, Frey NV, Siegel DL, Huang AC, Wherry EJ, Bitter H, Brogdon JL, Porter DL, June CH, Melenhorst JJ. Fraietta JA, et al. Among authors: orlando ej. Nat Med. 2018 May;24(5):563-571. doi: 10.1038/s41591-018-0010-1. Epub 2018 Apr 30. Nat Med. 2018. PMID: 29713085 Free PMC article.
Mechanisms of resistance to CAR T cell therapies.
Singh N, Orlando E, Xu J, Xu J, Binder Z, Collins MA, O'Rourke DM, Melenhorst JJ. Singh N, et al. Semin Cancer Biol. 2020 Oct;65:91-98. doi: 10.1016/j.semcancer.2019.12.002. Epub 2019 Dec 19. Semin Cancer Biol. 2020. PMID: 31866478 Free PMC article. Review.
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell.
Ruella M, Xu J, Barrett DM, Fraietta JA, Reich TJ, Ambrose DE, Klichinsky M, Shestova O, Patel PR, Kulikovskaya I, Nazimuddin F, Bhoj VG, Orlando EJ, Fry TJ, Bitter H, Maude SL, Levine BL, Nobles CL, Bushman FD, Young RM, Scholler J, Gill SI, June CH, Grupp SA, Lacey SF, Melenhorst JJ. Ruella M, et al. Among authors: orlando ej. Nat Med. 2018 Oct;24(10):1499-1503. doi: 10.1038/s41591-018-0201-9. Epub 2018 Oct 1. Nat Med. 2018. PMID: 30275568 Free PMC article.
Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia.
Orlando EJ, Han X, Tribouley C, Wood PA, Leary RJ, Riester M, Levine JE, Qayed M, Grupp SA, Boyer M, De Moerloose B, Nemecek ER, Bittencourt H, Hiramatsu H, Buechner J, Davies SM, Verneris MR, Nguyen K, Brogdon JL, Bitter H, Morrissey M, Pierog P, Pantano S, Engelman JA, Winckler W. Orlando EJ, et al. Nat Med. 2018 Oct;24(10):1504-1506. doi: 10.1038/s41591-018-0146-z. Epub 2018 Oct 1. Nat Med. 2018. PMID: 30275569
Author Correction: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia.
Fraietta JA, Lacey SF, Orlando EJ, Pruteanu-Malinici I, Gohil M, Lundh S, Boesteanu AC, Wang Y, O'Connor RS, Hwang WT, Pequignot E, Ambrose DE, Zhang C, Wilcox N, Bedoya F, Dorfmeier C, Chen F, Tian L, Parakandi H, Gupta M, Young RM, Johnson FB, Kulikovskaya I, Liu L, Xu J, Kassim SH, Davis MM, Levine BL, Frey NV, Siegel DL, Huang AC, Wherry EJ, Bitter H, Brogdon JL, Porter DL, June CH, Melenhorst JJ. Fraietta JA, et al. Among authors: orlando ej. Nat Med. 2021 Mar;27(3):561. doi: 10.1038/s41591-021-01248-2. Nat Med. 2021. PMID: 33547459 No abstract available.
Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction.
Singh N, Lee YG, Shestova O, Ravikumar P, Hayer KE, Hong SJ, Lu XM, Pajarillo R, Agarwal S, Kuramitsu S, Orlando EJ, Mueller KT, Good CR, Berger SL, Shalem O, Weitzman MD, Frey NV, Maude SL, Grupp SA, June CH, Gill S, Ruella M. Singh N, et al. Among authors: orlando ej. Cancer Discov. 2020 Apr;10(4):552-567. doi: 10.1158/2159-8290.CD-19-0813. Epub 2020 Jan 30. Cancer Discov. 2020. PMID: 32001516 Free PMC article.
Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma: Results from a Proof-of-Concept, Phase Ib Study.
Abdul Razak AR, Bauer S, Suarez C, Lin CC, Quek R, Hütter-Krönke ML, Cubedo R, Ferretti S, Guerreiro N, Jullion A, Orlando EJ, Clementi G, Sand Dejmek J, Halilovic E, Fabre C, Blay JY, Italiano A. Abdul Razak AR, et al. Among authors: orlando ej. Clin Cancer Res. 2022 Mar 15;28(6):1087-1097. doi: 10.1158/1078-0432.CCR-21-1291. Clin Cancer Res. 2022. PMID: 34921024 Clinical Trial.
Fermi gamma-ray imaging of a radio galaxy.
Fermi-LAT Collaboration; Abdo AA, Ackermann M, Ajello M, Atwood WB, Baldini L, Ballet J, Barbiellini G, Bastieri D, Baughman BM, Bechtol K, Bellazzini R, Berenji B, Blandford RD, Bloom ED, Bonamente E, Borgland AW, Bregeon J, Brez A, Brigida M, Bruel P, Burnett TH, Buson S, Caliandro GA, Cameron RA, Caraveo PA, Casandjian JM, Cavazzuti E, Cecchi C, Celik O, Chekhtman A, Cheung CC, Chiang J, Ciprini S, Claus R, Cohen-Tanugi J, Colafrancesco S, Cominsky LR, Conrad J, Costamante L, Cutini S, Davis DS, Dermer CD, de Angelis A, de Palma F, Digel SW, do Couto e Silva E, Drell PS, Dubois R, Dumora D, Farnier C, Favuzzi C, Fegan SJ, Finke J, Focke WB, Fortin P, Fukazawa Y, Funk S, Fusco P, Gargano F, Gasparrini D, Gehrels N, Georganopoulos M, Germani S, Giebels B, Giglietto N, Giordano F, Giroletti M, Glanzman T, Godfrey G, Grenier IA, Grove JE, Guillemot L, Guiriec S, Hanabata Y, Harding AK, Hayashida M, Hays E, Hughes RE, Jackson MS, Jóhannesson G, Johnson AS, Johnson TJ, Johnson WN, Kamae T, Katagiri H, Kataoka J, Kawai N, Kerr M, Knödlseder J, Kocian ML, Kuss M, Lande J, Latronico L, Lemoine-Goumard M, Longo F, Loparco F, Lott B, Lovellette MN, Lubrano P, Madejski GM, Makeev A, Mazzio… See abstract for full author list ➔ Fermi-LAT Collaboration, et al. Among authors: orlando e. Science. 2010 May 7;328(5979):725-9. doi: 10.1126/science.1184656. Epub 2010 Apr 1. Science. 2010. PMID: 20360067 Free article.
50 results