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Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.
Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, Crisponi L, Naitza S, Asunis I, Deiana M, Nagaraja R, Perseu L, Satta S, Cipollina MD, Sollaino C, Moi P, Hirschhorn JN, Orkin SH, Abecasis GR, Schlessinger D, Cao A. Uda M, et al. Among authors: orkin sh. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1620-5. doi: 10.1073/pnas.0711566105. Epub 2008 Feb 1. Proc Natl Acad Sci U S A. 2008. PMID: 18245381 Free PMC article.
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.
Lettre G, Sankaran VG, Bezerra MA, Araújo AS, Uda M, Sanna S, Cao A, Schlessinger D, Costa FF, Hirschhorn JN, Orkin SH. Lettre G, et al. Among authors: orkin sh. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11869-74. doi: 10.1073/pnas.0804799105. Epub 2008 Jul 30. Proc Natl Acad Sci U S A. 2008. PMID: 18667698 Free PMC article.
Rb and hematopoiesis: stem cells to anemia.
Walkley CR, Sankaran VG, Orkin SH. Walkley CR, et al. Among authors: orkin sh. Cell Div. 2008 Sep 8;3:13. doi: 10.1186/1747-1028-3-13. Cell Div. 2008. PMID: 18775080 Free PMC article.
Developmental and species-divergent globin switching are driven by BCL11A.
Sankaran VG, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH. Sankaran VG, et al. Among authors: orkin sh. Nature. 2009 Aug 27;460(7259):1093-7. doi: 10.1038/nature08243. Epub 2009 Aug 5. Nature. 2009. PMID: 19657335 Free PMC article.
Advances in the understanding of haemoglobin switching.
Sankaran VG, Xu J, Orkin SH. Sankaran VG, et al. Among authors: orkin sh. Br J Haematol. 2010 Apr;149(2):181-94. doi: 10.1111/j.1365-2141.2010.08105.x. Epub 2010 Mar 1. Br J Haematol. 2010. PMID: 20201948 Free PMC article. Review.
Transcriptional silencing of fetal hemoglobin by BCL11A.
Sankaran VG, Xu J, Orkin SH. Sankaran VG, et al. Among authors: orkin sh. Ann N Y Acad Sci. 2010 Aug;1202:64-8. doi: 10.1111/j.1749-6632.2010.05574.x. Ann N Y Acad Sci. 2010. PMID: 20712774
653 results