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Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.
Noji S, Hara Y, Miura T, Yamanaka H, Maeda K, Hori A, Yamamoto H, Obika S, Inoue M, Hase Y, Orita T, Doi S, Adachi T, Tanimoto A, Oki C, Kimoto Y, Ogawa Y, Negoro T, Hashimoto H, Shiozaki M. Noji S, et al. Among authors: orita t. J Med Chem. 2020 Jul 9;63(13):7163-7185. doi: 10.1021/acs.jmedchem.0c00450. Epub 2020 Jun 29. J Med Chem. 2020. PMID: 32511913
Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney.
Higuchi T, Orita T, Nakanishi S, Katsuya K, Watanabe H, Yamasaki Y, Waga I, Nanayama T, Yamamoto Y, Munger W, Sun HW, Falk RJ, Jennette JC, Alcorta DA, Li H, Yamamoto T, Saito Y, Nakamura M. Higuchi T, et al. Among authors: orita t. J Biol Chem. 2004 Jan 16;279(3):1968-79. doi: 10.1074/jbc.M304558200. Epub 2003 Oct 17. J Biol Chem. 2004. PMID: 14565953 Free article.
Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide.
Ohba Y, Adachi K, Furukawa T, Nishimaru T, Sakurai K, Masuo R, Inami T, Orita T, Akai S, Adachi T, Usui K, Hamada Y, Mori M, Kurimoto T, Wakashima T, Akiyama Y, Miyazaki S, Noji S. Ohba Y, et al. Among authors: orita t. ACS Med Chem Lett. 2023 Nov 10;14(12):1833-1838. doi: 10.1021/acsmedchemlett.3c00433. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116417
PRELP Regulates Cell-Cell Adhesion and EMT and Inhibits Retinoblastoma Progression.
Hopkins J, Asada K, Leung A, Papadaki V, Davaapil H, Morrison M, Orita T, Sekido R, Kosuge H, Reddy MA, Kimura K, Mitani A, Tsumoto K, Hamamoto R, Sagoo MS, Ohnuma SI. Hopkins J, et al. Among authors: orita t. Cancers (Basel). 2022 Oct 8;14(19):4926. doi: 10.3390/cancers14194926. Cancers (Basel). 2022. PMID: 36230849 Free PMC article.
177 results