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Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease.
Ko JY, Wang FS, Lian WS, Yang FS, Chen JW, Huang PH, Liao CY, Kuo SJ. Ko JY, et al. Mol Med. 2024 May 21;30(1):66. doi: 10.1186/s10020-024-00838-3. Mol Med. 2024. PMID: 38773377
BACKGROUND: The current treatment of osteogenesis imperfecta (OI) is imperfect. Our study thus delves into the potential of using Dickkopf-1 antisense (DKK1-AS) to treat OI. ...Bone tissues from OI mice treated with DKK1-AS exhibited significantly higher brea …
BACKGROUND: The current treatment of osteogenesis imperfecta (OI) is imperfect. Our study thus delves into the potential of using Dic …
A recurrent de novo missense mutation in COL1A1 causes osteogenesis imperfecta type II and preterm delivery in Normande cattle.
Corbeau J, Grohs C, Jourdain J, Boussaha M, Besnard F, Barbat A, Plassard V, Rivière J, Hamelin C, Mortier J, Boichard D, Guatteo R, Capitan A. Corbeau J, et al. Genet Sel Evol. 2024 May 21;56(1):39. doi: 10.1186/s12711-024-00909-3. Genet Sel Evol. 2024. PMID: 38773368
Interestingly, the affected residue was completely conserved among 243 vertebrate orthologs, and the same substitution in humans has been reported to cause type II osteogenesis imperfecta (OI), a connective tissue disorder that is characterized primarily by bone deformity …
Interestingly, the affected residue was completely conserved among 243 vertebrate orthologs, and the same substitution in humans has been re …
Noninvasive Surrogate for Physiologic Dead Space Using the Carbon Dioxide Ventilatory Equivalent: Testing in a Single-Center Cohort, 2017-2023.
Bhalla AK, Klein MJ, Hotz J, Kwok J, Bonilla-Cartagena JE, Baron DA, Kohler K, Bornstein D, Chang D, Vu K, Armenta-Quiroz A, Nelson LP, Newth CJL, Khemani RG. Bhalla AK, et al. Pediatr Crit Care Med. 2024 May 21. doi: 10.1097/PCC.0000000000003539. Online ahead of print. Pediatr Crit Care Med. 2024. PMID: 38771137
The 131 children had a median (interquartile range, IQR) age of 5.8 (IQR 1.4, 12.6) years, oxygenation index (OI) of 7.5 (IQR 4.6, 14.3), VD/Vt of 0.47 (IQR 0.38, 0.61), and mortality was 17.6% (23/131). Higher VEqco2 (p = 0.003), VD/Vt (p = 0.002), and VR (p = 0.013) were …
The 131 children had a median (interquartile range, IQR) age of 5.8 (IQR 1.4, 12.6) years, oxygenation index (OI) of 7.5 (IQR 4.6, 14 …
A case of osteogenesis imperfecta diagnosed after subchondral insufficiency fracture of bilateral femoral heads.
Okada N, Watarai K, Ozawa K, Miyajima T, Ohtake A, Kadono Y. Okada N, et al. Mod Rheumatol Case Rep. 2024 May 4:rxae021. doi: 10.1093/mrcr/rxae021. Online ahead of print. Mod Rheumatol Case Rep. 2024. PMID: 38771101
Osteogenesis imperfecta (OI) is a heterogeneous disorder characterised by bone fragility. Herein, we report a case of OI diagnosed after subchondral insufficiency fracture (SIF) of bilateral femoral heads. ...
Osteogenesis imperfecta (OI) is a heterogeneous disorder characterised by bone fragility. Herein, we report a case of OI diagn …
Open innovation and confidentiality agreements as key factors of innovative performance in the manufacturing and service industries.
Barrios Aguirre F, Alvarez Ovalle DM, Riveros Chávez NM, Martinez Garcia CJ. Barrios Aguirre F, et al. PLoS One. 2024 May 20;19(5):e0303802. doi: 10.1371/journal.pone.0303802. eCollection 2024. PLoS One. 2024. PMID: 38768189 Free PMC article.
The innovative performance of manufacturing and service companies can be impacted by the existing relationship between open innovation (OI) and the generation of confidentiality agreements (NDAs) as a tool for the protection of intellectual property. ...It could be deduced …
The innovative performance of manufacturing and service companies can be impacted by the existing relationship between open innovation (O …
4-Octyl itaconate alleviates dextran sulfate sodium-induced ulcerative colitis in mice via activating the KEAP1-NRF2 pathway.
Wang Y, Zhao X, Gao Y, Zhao C, Li J, Wang S, Xue B, Liu C, Ma X. Wang Y, et al. Inflammopharmacology. 2024 May 20. doi: 10.1007/s10787-024-01490-3. Online ahead of print. Inflammopharmacology. 2024. PMID: 38767761
In addition, ML385, a NRF2 antagonist, can inhibit the protective effects of OI on UC, indicating that the role of OI in this colitis model could be dependent on the activation of KEAP1-NRF2 pathway. Notably, OI co-administration significantly enhanced the th …
In addition, ML385, a NRF2 antagonist, can inhibit the protective effects of OI on UC, indicating that the role of OI in this …
α-Glucosidase inhibitory potential of Oroxylum indicum using molecular docking, molecular dynamics, and in vitro evaluation.
Bhaumik S, Sarkar A, Debnath S, Debnath B, Ghosh R, Zaki MEA, Al-Hussain SA. Bhaumik S, et al. Saudi Pharm J. 2024 Jun;32(6):102095. doi: 10.1016/j.jsps.2024.102095. Epub 2024 May 3. Saudi Pharm J. 2024. PMID: 38766274 Free PMC article.
Finally, in silico results were validated by in vitro analysis using n-butanol fraction of crude methanol extracts. RESULTS: The XP glide scores of top seven hits OI_13, OI_66, OI_16, OI_44, OI_43, OI_20, OI_78 and acarbose were -1 …
Finally, in silico results were validated by in vitro analysis using n-butanol fraction of crude methanol extracts. RESULTS: The XP glide sc …
Statins use and recurrent venous thromboembolism in the direct oral anticoagulant era: insight from the COMMAND VTE Registry-2.
Mabuchi H, Nishikawa R, Yamashita Y, Morimoto T, Chatani R, Kaneda K, Nishimoto Y, Ikeda N, Kobayashi Y, Ikeda S, Kim K, Inoko M, Takase T, Tsuji S, Oi M, Takada T, Otsui K, Sakamoto J, Ogihara Y, Inoue T, Usami S, Chen PM, Togi K, Koitabashi N, Hiramori S, Doi K, Tsuyuki Y, Murata K, Takabayashi K, Nakai H, Sueta D, Shioyama W, Dohke T, Ono K, Nakagawa Y, Kimura T. Mabuchi H, et al. J Thromb Thrombolysis. 2024 May 18. doi: 10.1007/s11239-024-03002-0. Online ahead of print. J Thromb Thrombolysis. 2024. PMID: 38762713
4-Octyl Itaconate Attenuates Neuroinflammation in Experimental Autoimmune Encephalomyelitis Via Regulating Microglia.
Zhao N, Yi M, Zhang LJ, Zhang QX, Yang L. Zhao N, et al. Inflammation. 2024 May 18. doi: 10.1007/s10753-024-02050-1. Online ahead of print. Inflammation. 2024. PMID: 38761250
BV2 microglia were used to further investigate the effects and mechanisms of action of 4-OI in vitro. 4-OI significantly alleviated the clinical symptoms of EAE, the inflammatory infiltration, and demyelination; reduced the levels of inflammatory factors; and inhibi …
BV2 microglia were used to further investigate the effects and mechanisms of action of 4-OI in vitro. 4-OI significantly allev …
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