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Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency.
Orgován Z, Péczka N, Petri L, Ábrányi-Balogh P, Ranđelović I, Tóth S, Szakács G, Nyíri K, Vértessy B, Pálfy G, Vida I, Perczel A, Tóvári J, Keserű GM. Orgován Z, et al. Eur J Med Chem. 2023 Mar 15;250:115212. doi: 10.1016/j.ejmech.2023.115212. Epub 2023 Feb 15. Eur J Med Chem. 2023. PMID: 36842271 Free article.
Structural impact of GTP binding on downstream KRAS signaling.
Menyhárd DK, Pálfy G, Orgován Z, Vida I, Keserű GM, Perczel A. Menyhárd DK, et al. Among authors: orgovan z. Chem Sci. 2020 Aug 19;11(34):9272-9289. doi: 10.1039/d0sc03441j. Chem Sci. 2020. PMID: 34094198 Free PMC article.
Electrophilic warheads in covalent drug discovery: an overview.
Péczka N, Orgován Z, Ábrányi-Balogh P, Keserű GM. Péczka N, et al. Among authors: orgovan z. Expert Opin Drug Discov. 2022 Apr;17(4):413-422. doi: 10.1080/17460441.2022.2034783. Epub 2022 Feb 6. Expert Opin Drug Discov. 2022. PMID: 35129005 Review.
[Allele-specific inhibitors of mutant KRAS are in the focus of RASopathy consortium].
Nyíri K, Koppány G, Pálfy G, Vida I, Tóth S, Orgován Z, Ranđelović I, Baranyi M, Molnár E, Keserû MG, Tóvári J, Perczel A, Vértessy BG, Tímár J. Nyíri K, et al. Among authors: orgovan z. Magy Onkol. 2019 Dec 9;63(4):310-323. Epub 2019 Nov 25. Magy Onkol. 2019. PMID: 31821386 Free article. Hungarian.
Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulators.
Galambos J, Bielik A, Wágner G, Domány G, Kóti J, Béni Z, Szigetvári Á, Sánta Z, Orgován Z, Bobok A, Kiss B, Mikó-Bakk ML, Vastag M, Sághy K, Krasavin M, Gál K, Greiner I, Szombathelyi Z, Keserű GM. Galambos J, et al. Among authors: orgovan z. Eur J Med Chem. 2017 Jun 16;133:240-254. doi: 10.1016/j.ejmech.2017.03.071. Epub 2017 Mar 29. Eur J Med Chem. 2017. PMID: 28390229
Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.
Christopher JA, Orgován Z, Congreve M, Doré AS, Errey JC, Marshall FH, Mason JS, Okrasa K, Rucktooa P, Serrano-Vega MJ, Ferenczy GG, Keserű GM. Christopher JA, et al. Among authors: orgovan z. J Med Chem. 2019 Jan 10;62(1):207-222. doi: 10.1021/acs.jmedchem.7b01722. Epub 2018 Mar 1. J Med Chem. 2019. PMID: 29455526
17 results