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Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance.
Orgaz JL, Crosas-Molist E, Sadok A, Perdrix-Rosell A, Maiques O, Rodriguez-Hernandez I, Monger J, Mele S, Georgouli M, Bridgeman V, Karagiannis P, Lee R, Pandya P, Boehme L, Wallberg F, Tape C, Karagiannis SN, Malanchi I, Sanz-Moreno V. Orgaz JL, et al. Cancer Cell. 2020 Jan 13;37(1):85-103.e9. doi: 10.1016/j.ccell.2019.12.003. Cancer Cell. 2020. PMID: 31935375 Free PMC article.
Diverse matrix metalloproteinase functions regulate cancer amoeboid migration.
Orgaz JL, Pandya P, Dalmeida R, Karagiannis P, Sanchez-Laorden B, Viros A, Albrengues J, Nestle FO, Ridley AJ, Gaggioli C, Marais R, Karagiannis SN, Sanz-Moreno V. Orgaz JL, et al. Nat Commun. 2014 Jun 25;5:4255. doi: 10.1038/ncomms5255. Nat Commun. 2014. PMID: 24963846 Free PMC article.
TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination.
Cantelli G, Orgaz JL, Rodriguez-Hernandez I, Karagiannis P, Maiques O, Matias-Guiu X, Nestle FO, Marti RM, Karagiannis SN, Sanz-Moreno V. Cantelli G, et al. Among authors: orgaz jl. Curr Biol. 2015 Nov 16;25(22):2899-914. doi: 10.1016/j.cub.2015.09.054. Epub 2015 Oct 29. Curr Biol. 2015. PMID: 26526369 Free PMC article.
Modes of invasion during tumour dissemination.
Pandya P, Orgaz JL, Sanz-Moreno V. Pandya P, et al. Among authors: orgaz jl. Mol Oncol. 2017 Jan;11(1):5-27. doi: 10.1002/1878-0261.12019. Epub 2016 Dec 9. Mol Oncol. 2017. PMID: 28085224 Free PMC article. Review.
T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1.
Maiques O, Barceló C, Panosa A, Pijuan J, Orgaz JL, Rodriguez-Hernandez I, Matas-Nadal C, Tell G, Vilella R, Fabra A, Puig S, Sanz-Moreno V, Matias-Guiu X, Canti C, Herreros J, Marti RM, Macià A. Maiques O, et al. Among authors: orgaz jl. Pigment Cell Melanoma Res. 2018 Jul;31(4):484-495. doi: 10.1111/pcmr.12690. Epub 2018 Feb 18. Pigment Cell Melanoma Res. 2018. PMID: 29385656 Free article.
Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.
Georgouli M, Herraiz C, Crosas-Molist E, Fanshawe B, Maiques O, Perdrix A, Pandya P, Rodriguez-Hernandez I, Ilieva KM, Cantelli G, Karagiannis P, Mele S, Lam H, Josephs DH, Matias-Guiu X, Marti RM, Nestle FO, Orgaz JL, Malanchi I, Fruhwirth GO, Karagiannis SN, Sanz-Moreno V. Georgouli M, et al. Among authors: orgaz jl. Cell. 2019 Feb 7;176(4):757-774.e23. doi: 10.1016/j.cell.2018.12.038. Epub 2019 Jan 31. Cell. 2019. PMID: 30712866 Free PMC article.
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