Orellana EA - Search Results

1

Structural basis of regulated m⁷G tRNA modification by METTL1-WDR4.

Li J, Wang L, Hahn Q, Nowak RP, Viennet T, Orellana EA, Roy Burman SS, Yue H, Hunkeler M, Fontana P, Wu H, Arthanari H, Fischer ES, Gregory RI. Li J, et al. Among authors: orellana ea. Nature. 2023 Jan;613(7943):391-397. doi: 10.1038/s41586-022-05566-4. Epub 2023 Jan 4. Nature. 2023. PMID: 36599985

2

METTL1-mediated m⁷G modification of Arg-TCT tRNA drives oncogenic transformation.

Orellana EA, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos DA, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes GJL, Fischer ES, Bradley A, Vassiliou GS, Slack FJ, Tzelepis K, Gregory RI. Orellana EA, et al. Mol Cell. 2021 Aug 19;81(16):3323-3338.e14. doi: 10.1016/j.molcel.2021.06.031. Epub 2021 Aug 4. Mol Cell. 2021. PMID: 34352207 Free PMC article.

3

tRNA dysregulation and disease.

Orellana EA, Siegal E, Gregory RI. Orellana EA, et al. Nat Rev Genet. 2022 Nov;23(11):651-664. doi: 10.1038/s41576-022-00501-9. Epub 2022 Jun 9. Nat Rev Genet. 2022. PMID: 35681060 Review.

4

METTL4 is an snRNA m⁶Am methyltransferase that regulates RNA splicing.

Chen H, Gu L, Orellana EA, Wang Y, Guo J, Liu Q, Wang L, Shen Z, Wu H, Gregory RI, Xing Y, Shi Y. Chen H, et al. Among authors: orellana ea. Cell Res. 2020 Jun;30(6):544-547. doi: 10.1038/s41422-019-0270-4. Epub 2020 Jan 8. Cell Res. 2020. PMID: 31913360 Free PMC article. No abstract available.

5

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias.

Hinze L, Pfirrmann M, Karim S, Degar J, McGuckin C, Vinjamur D, Sacher J, Stevenson KE, Neuberg DS, Orellana E, Stanulla M, Gregory RI, Bauer DE, Wagner FF, Stegmaier K, Gutierrez A. Hinze L, et al. Cancer Cell. 2019 Apr 15;35(4):664-676.e7. doi: 10.1016/j.ccell.2019.03.004. Cancer Cell. 2019. PMID: 30991026 Free PMC article.

6

Identification and validation of microRNAs that synergize with miR-34a - a basis for combinatorial microRNA therapeutics.

Orellana EA, Li C, Lisevick A, Kasinski AL. Orellana EA, et al. Cell Cycle. 2019 Aug;18(15):1798-1811. doi: 10.1080/15384101.2019.1634956. Epub 2019 Jul 1. Cell Cycle. 2019. PMID: 31258013 Free PMC article.

7

FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer.

Orellana EA, Tenneti S, Rangasamy L, Lyle LT, Low PS, Kasinski AL. Orellana EA, et al. Sci Transl Med. 2017 Aug 2;9(401):eaam9327. doi: 10.1126/scitranslmed.aam9327. Sci Transl Med. 2017. PMID: 28768807 Free PMC article.

8

A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer.

Kasinski AL, Kelnar K, Stahlhut C, Orellana E, Zhao J, Shimer E, Dysart S, Chen X, Bader AG, Slack FJ. Kasinski AL, et al. Oncogene. 2015 Jul;34(27):3547-55. doi: 10.1038/onc.2014.282. Epub 2014 Sep 1. Oncogene. 2015. PMID: 25174400 Free PMC article.

9

Enhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin.

Orellana EA, Abdelaal AM, Rangasamy L, Tenneti S, Myoung S, Low PS, Kasinski AL. Orellana EA, et al. Mol Ther Nucleic Acids. 2019 Jun 7;16:505-518. doi: 10.1016/j.omtn.2019.04.003. Epub 2019 Apr 11. Mol Ther Nucleic Acids. 2019. PMID: 31071527 Free PMC article.

10

Selective targeting of chemically modified miR-34a to prostate cancer using a small molecule ligand and an endosomal escape agent.

Abdelaal AM, Sohal IS, Iyer SG, Sudarshan K, Orellana EA, Ozcan KE, Dos Santos AP, Low PS, Kasinski AL. Abdelaal AM, et al. Among authors: orellana ea. Mol Ther Nucleic Acids. 2024 Apr 23;35(2):102193. doi: 10.1016/j.omtn.2024.102193. eCollection 2024 Jun 11. Mol Ther Nucleic Acids. 2024. PMID: 38745855 Free PMC article.

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