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Precision medicine in type 1 diabetes.
Carr ALJ, Evans-Molina C, Oram RA. Carr ALJ, et al. Among authors: oram ra. Diabetologia. 2022 Nov;65(11):1854-1866. doi: 10.1007/s00125-022-05778-3. Epub 2022 Aug 22. Diabetologia. 2022. PMID: 35994083 Free PMC article. Review.
Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes.
Roshandel D, Gubitosi-Klug R, Bull SB, Canty AJ, Pezzolesi MG, King GL, Keenan HA, Snell-Bergeon JK, Maahs DM, Klein R, Klein BEK, Orchard TJ, Costacou T, Weedon MN; DCCT/EDIC Research Group; Oram RA, Paterson AD. Roshandel D, et al. Among authors: oram ra. Diabetologia. 2018 May;61(5):1098-1111. doi: 10.1007/s00125-018-4555-9. Epub 2018 Feb 5. Diabetologia. 2018. PMID: 29404672 Free PMC article.
Clinical and research uses of genetic risk scores in type 1 diabetes.
Sharp SA, Weedon MN, Hagopian WA, Oram RA. Sharp SA, et al. Among authors: oram ra. Curr Opin Genet Dev. 2018 Jun;50:96-102. doi: 10.1016/j.gde.2018.03.009. Epub 2018 Apr 24. Curr Opin Genet Dev. 2018. PMID: 29702327 Free PMC article. Review.
Type 1 diabetes.
DiMeglio LA, Evans-Molina C, Oram RA. DiMeglio LA, et al. Among authors: oram ra. Lancet. 2018 Jun 16;391(10138):2449-2462. doi: 10.1016/S0140-6736(18)31320-5. Lancet. 2018. PMID: 29916386 Free PMC article. Review.
A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.
Redondo MJ, Geyer S, Steck AK, Sharp S, Wentworth JM, Weedon MN, Antinozzi P, Sosenko J, Atkinson M, Pugliese A, Oram RA; Type 1 Diabetes TrialNet Study Group. Redondo MJ, et al. Among authors: oram ra. Diabetes Care. 2018 Sep;41(9):1887-1894. doi: 10.2337/dc18-0087. Epub 2018 Jul 12. Diabetes Care. 2018. PMID: 30002199 Free PMC article.
Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.
Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M. Battaglia M, et al. Among authors: oram ra. Diabetes Care. 2020 Jan;43(1):5-12. doi: 10.2337/dc19-0880. Epub 2019 Nov 21. Diabetes Care. 2020. PMID: 31753960 Free PMC article.
Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis.
Leete P, Oram RA, McDonald TJ, Shields BM, Ziller C; TIGI study team; Hattersley AT, Richardson SJ, Morgan NG. Leete P, et al. Among authors: oram ra. Diabetologia. 2020 Jun;63(6):1258-1267. doi: 10.1007/s00125-020-05115-6. Epub 2020 Mar 15. Diabetologia. 2020. PMID: 32172310 Free PMC article.
119 results