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Generation of iPSC lines with SLC16A2:G401R or SLC16A2 knock out.
Ludwik KA, Opitz R, Jyrch S, Megges M, Weiner J, Beule D, Kühnen P, Stachelscheid H. Ludwik KA, et al. Among authors: opitz r. Stem Cell Res. 2023 Dec;73:103256. doi: 10.1016/j.scr.2023.103256. Epub 2023 Nov 21. Stem Cell Res. 2023. PMID: 38006677 Free article.
Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment.
Lechner L, Opitz R, Silver MJ, Krabusch PM, Prentice AM, Field MS, Stachelscheid H, Leitão E, Schröder C, Fernandez Vallone V, Horsthemke B, Jöckel KH, Schmidt B, Nöthen MM, Hoffmann P, Herms S, Kleyn PW, Megges M, Blume-Peytavi U, Weiss K, Mai K, Blankenstein O, Obermayer B, Wiegand S, Kühnen P. Lechner L, et al. Among authors: opitz r. Sci Transl Med. 2023 Jul 19;15(705):eadg1659. doi: 10.1126/scitranslmed.adg1659. Epub 2023 Jul 19. Sci Transl Med. 2023. PMID: 37467315
Creating an Earth Archive.
Fisher C, Leisz S, Evans D, Wall DH, Galvin K, Laituri M, Henebry G, Zeidler J, Fernandez-Diaz JC, Pallickara S, Pallickara S, Garrison T, Estrada-Belli F, Neves E, Reese-Taylor K, Opitz R, Lovejoy T, Sarni W, Solinis R, Ellis G, Carvalho M, White C, Daggars L, Gasson-Pacheco RA, Bolaños A, Scarborough V. Fisher C, et al. Among authors: opitz r. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2115485119. doi: 10.1073/pnas.2115485119. Epub 2022 Mar 9. Proc Natl Acad Sci U S A. 2022. PMID: 35263218 Free PMC article. No abstract available.
Cardiac Phenotype and Tissue Sodium Content in Adolescents With Defects in the Melanocortin System.
Puder L, Roth S, Krabusch P, Wiegand S, Opitz R, Bald M, Flück C, Schulz E, Voss E, Markó L, Linz P, Berger F, Müller DN, Kuehne T, Litt MJ, Cone RD, Kühnen P, Kelm M. Puder L, et al. Among authors: opitz r. J Clin Endocrinol Metab. 2021 Aug 18;106(9):2606-2616. doi: 10.1210/clinem/dgab368. J Clin Endocrinol Metab. 2021. PMID: 34036349 Free PMC article.
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone M, Müller M, Chiha S, Ren J, Albat D, Soicke A, Dohmen S, Klein M, Bruns J, van Dinther M, Opitz R, Lindemann P, Beerbaum M, Motzny K, Roske Y, Schmieder P, Volkmer R, Nazaré M, Heinemann U, Oschkinat H, Ten Dijke P, Schmalz HG, Kühne R. Barone M, et al. Among authors: opitz r. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29684-29690. doi: 10.1073/pnas.2007213117. Epub 2020 Nov 12. Proc Natl Acad Sci U S A. 2020. PMID: 33184177 Free PMC article.
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