Opavsky R - Search Results

1

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions.

Nowialis P, Lopusna K, Opavska J, Haney SL, Abraham A, Sheng P, Riva A, Natarajan A, Guryanova O, Simpson M, Hlady R, Xie M, Opavsky R. Nowialis P, et al. Among authors: opavsky r. Nat Commun. 2019 Sep 26;10(1):4374. doi: 10.1038/s41467-019-12355-7. Nat Commun. 2019. PMID: 31558711 Free PMC article.

2

Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.

Haney SL, Hlady RA, Opavska J, Klinkebiel D, Pirruccello SJ, Dutta S, Datta K, Simpson MA, Wu L, Opavsky R. Haney SL, et al. Among authors: opavsky r. Oncogene. 2015 Oct;34(43):5436-5446. doi: 10.1038/onc.2014.472. Epub 2015 Feb 2. Oncogene. 2015. PMID: 25639876 Free PMC article.

3

Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling.

Lopusna K, Nowialis P, Opavska J, Abraham A, Riva A, Opavsky R. Lopusna K, et al. Among authors: opavsky r. EBioMedicine. 2021 Jan;63:103191. doi: 10.1016/j.ebiom.2020.103191. Epub 2021 Jan 6. EBioMedicine. 2021. PMID: 33418509 Free PMC article.

4

Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.

Lopusna K, Nowialis P, Opavska J, Abraham A, Riva A, Haney SL, Opavsky R. Lopusna K, et al. Among authors: opavsky r. J Biol Chem. 2021 Jan-Jun;296:100285. doi: 10.1016/j.jbc.2021.100285. Epub 2021 Jan 13. J Biol Chem. 2021. PMID: 33450231 Free PMC article.

5

Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis.

Peters SL, Hlady RA, Opavska J, Klinkebiel D, Pirruccello SJ, Talmon GA, Sharp JG, Wu L, Jaenisch R, Simpson MA, Karpf AR, Opavsky R. Peters SL, et al. Among authors: opavsky r. Leukemia. 2014 May;28(5):1138-42. doi: 10.1038/leu.2013.364. Epub 2013 Dec 2. Leukemia. 2014. PMID: 24292811 No abstract available.

6

Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis.

Hlady RA, Novakova S, Opavska J, Klinkebiel D, Peters SL, Bies J, Hannah J, Iqbal J, Anderson KM, Siebler HM, Smith LM, Greiner TC, Bastola D, Joshi S, Lockridge O, Simpson MA, Felsher DW, Wagner KU, Chan WC, Christman JK, Opavsky R. Hlady RA, et al. Among authors: opavsky r. J Clin Invest. 2012 Jan;122(1):163-77. doi: 10.1172/JCI57292. Epub 2011 Dec 1. J Clin Invest. 2012. PMID: 22133874 Free PMC article.

7

Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas.

Peters SL, Hlady RA, Opavska J, Klinkebiel D, Novakova S, Smith LM, Lewis RE, Karpf AR, Simpson MA, Wu L, Opavsky R. Peters SL, et al. Among authors: opavsky r. Mol Cell Biol. 2013 Nov;33(21):4321-33. doi: 10.1128/MCB.00776-13. Epub 2013 Sep 3. Mol Cell Biol. 2013. PMID: 24001767 Free PMC article.

8

Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a.

Haney SL, Upchurch GM, Opavska J, Klinkebiel D, Hlady RA, Suresh A, Pirruccello SJ, Shukla V, Lu R, Costinean S, Rizzino A, Karpf AR, Joshi S, Swanson P, Opavsky R. Haney SL, et al. Among authors: opavsky r. Cell Rep. 2016 May 10;15(6):1190-201. doi: 10.1016/j.celrep.2016.04.004. Epub 2016 Apr 28. Cell Rep. 2016. PMID: 27134162 Free PMC article.

9

Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.

Haney SL, Upchurch GM, Opavska J, Klinkebiel D, Hlady RA, Roy S, Dutta S, Datta K, Opavsky R. Haney SL, et al. Among authors: opavsky r. PLoS Genet. 2016 Sep 30;12(9):e1006334. doi: 10.1371/journal.pgen.1006334. eCollection 2016 Sep. PLoS Genet. 2016. PMID: 27690235 Free PMC article.

10

Mouse development with a single E2F activator.

Tsai SY, Opavsky R, Sharma N, Wu L, Naidu S, Nolan E, Feria-Arias E, Timmers C, Opavska J, de Bruin A, Chong JL, Trikha P, Fernandez SA, Stromberg P, Rosol TJ, Leone G. Tsai SY, et al. Among authors: opavsky r. Nature. 2008 Aug 28;454(7208):1137-41. doi: 10.1038/nature07066. Epub 2008 Jun 25. Nature. 2008. PMID: 18594513 Free PMC article.

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