Oosterom J - Search Results

1

High-throughput screening using beta-lactamase reporter-gene technology for identification of low-molecular-weight antagonists of the human gonadotropin releasing hormone receptor.

Oosterom J, van Doornmalen EJ, Lobregt S, Blomenröhr M, Zaman GJ. Oosterom J, et al. Assay Drug Dev Technol. 2005 Apr;3(2):143-54. doi: 10.1089/adt.2005.3.143. Assay Drug Dev Technol. 2005. PMID: 15871689

2

Cryopreserved cells facilitate cell-based drug discovery.

Zaman GJ, de Roos JA, Blomenröhr M, van Koppen CJ, Oosterom J. Zaman GJ, et al. Among authors: oosterom j. Drug Discov Today. 2007 Jul;12(13-14):521-6. doi: 10.1016/j.drudis.2007.05.008. Epub 2007 Jun 27. Drug Discov Today. 2007. PMID: 17631245 Review.

3

C5a-stimulated recruitment of beta-arrestin2 to the nonsignaling 7-transmembrane decoy receptor C5L2.

Van Lith LH, Oosterom J, Van Elsas A, Zaman GJ. Van Lith LH, et al. Among authors: oosterom j. J Biomol Screen. 2009 Oct;14(9):1067-75. doi: 10.1177/1087057109341407. Epub 2009 Jul 29. J Biomol Screen. 2009. PMID: 19641221

4

Identification of substituted 6-amino-4-phenyltetrahydroquinoline derivatives: potent antagonists for the follicle-stimulating hormone receptor.

van Straten NC, van Berkel TH, Demont DR, Karstens WJ, Merkx R, Oosterom J, Schulz J, van Someren RG, Timmers CM, van Zandvoort PM. van Straten NC, et al. Among authors: oosterom j. J Med Chem. 2005 Mar 24;48(6):1697-700. doi: 10.1021/jm049676l. J Med Chem. 2005. PMID: 15771412

5

Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor.

Heitman LH, Ye K, Oosterom J, Ijzerman AP. Heitman LH, et al. Among authors: oosterom j. Mol Pharmacol. 2008 Jun;73(6):1808-15. doi: 10.1124/mol.107.043521. Epub 2008 Mar 14. Mol Pharmacol. 2008. PMID: 18344315

6

[3H]Org 43553, the first low-molecular-weight agonistic and allosteric radioligand for the human luteinizing hormone receptor.

Heitman LH, Oosterom J, Bonger KM, Timmers CM, Wiegerinck PH, Ijzerman AP. Heitman LH, et al. Among authors: oosterom j. Mol Pharmacol. 2008 Feb;73(2):518-24. doi: 10.1124/mol.107.039875. Epub 2007 Nov 7. Mol Pharmacol. 2008. PMID: 17989351

7

Synthesis and evaluation of homo-bivalent GnRHR ligands.

Bonger KM, van den Berg RJ, Heitman LH, IJzerman AP, Oosterom J, Timmers CM, Overkleeft HS, van der Marel GA. Bonger KM, et al. Among authors: oosterom j. Bioorg Med Chem. 2007 Jul 15;15(14):4841-56. doi: 10.1016/j.bmc.2007.04.065. Epub 2007 May 6. Bioorg Med Chem. 2007. PMID: 17517510

8

Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core.

Bonger KM, van den Berg RJ, Knijnenburg AD, Heitman LH, Ijzerman AP, Oosterom J, Timmers CM, Overkleeft HS, van der Marel GA. Bonger KM, et al. Among authors: oosterom j. Bioorg Med Chem. 2008 Apr 1;16(7):3744-58. doi: 10.1016/j.bmc.2008.01.054. Epub 2008 Feb 2. Bioorg Med Chem. 2008. PMID: 18282756

9

Identification of antagonists for melanocortin MC3, MC4 and MC5 receptors.

Adan RA, Oosterom J, Ludvigsdottir G, Brakkee JH, Burbach JP, Gispen WH. Adan RA, et al. Among authors: oosterom j. Eur J Pharmacol. 1994 Nov 15;269(3):331-7. doi: 10.1016/0922-4106(94)90041-8. Eur J Pharmacol. 1994. PMID: 7895772

10

Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists.

van der Stelt M, Cals J, Broeders-Josten S, Cottney J, van der Doelen AA, Hermkens M, de Kimpe V, King A, Klomp J, Oosterom J, Pols-de Rooij I, de Roos J, van Tilborg M, Boyce S, Baker J. van der Stelt M, et al. Among authors: oosterom j. J Med Chem. 2011 Oct 27;54(20):7350-62. doi: 10.1021/jm200916p. Epub 2011 Sep 29. J Med Chem. 2011. PMID: 21923175

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